Tìm theo
Tecadenoson
Thuốc chống loạn nhịp
Thuốc Gốc
Small Molecule
CAS: 204512-90-3
CTHH: C14H19N5O5
PTK: 337.3312
Tecadenoson is a novel selective A1 adenosine receptor agonist that is currently being evaluated for the conversion of paroxysmal supraventricular tachycardia (PSVT) to sinus rhythm. It is being developed by CV Therapeutics, Inc.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H19N5O5
Phân tử khối
337.3312
Monoisotopic mass
337.138618743
InChI
InChI=1S/C14H19N5O5/c20-3-8-10(21)11(22)14(24-8)19-6-17-9-12(15-5-16-13(9)19)18-7-1-2-23-4-7/h5-8,10-11,14,20-22H,1-4H2,(H,15,16,18)/t7-,8-,10-,11-,14-/m1/s1
InChI Key
InChIKey=OESBDSFYJMDRJY-BAYCTPFLSA-N
IUPAC Name
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-{[(3R)-oxolan-3-yl]amino}-9H-purin-9-yl)oxolane-3,4-diol
Traditional IUPAC Name
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-{6-[(3R)-oxolan-3-ylamino]purin-9-yl}oxolane-3,4-diol
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N[C@@H]3CCOC3)N=CN=C12
Độ hòa tan
8.22e+00 g/l
logP
-1.9
logS
-1.6
pKa (strongest acidic)
12.45
pKa (Strongest Basic)
4.84
PSA
134.78 Å2
Refractivity
82.3 m3·mol-1
Polarizability
33.24 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
9
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Dược Lực Học : Tecadenoson is a novel A1 adenosine receptor stimulator. Adenosine is a naturally occurring compound that stimulates all adenosine receptor subtypes in the body, including the A2 adenosine receptor which lowers blood pressure. In non-clinical trials, tecadenoson selectively stimulated the A1 adenosine receptor in the AV node and slowed the speed of electrical conduction across the AV node, reducing the number of electrical impulses that reached the ventricle, without affecting blood pressure. Clinical studies to date with intravenous tecadenoson suggest that it may slow the speed of AV nodal conduction by selectively stimulating the A1 adenosine receptor, and may avoid blood pressure lowering by not stimulating the A2 adenosine receptor. Thus, it may be possible to use intravenous tecadenoson to convert patients from PSVT to normal sinus rhythm without lowering blood pressure or causing adverse events related to vasodilitation such as flushing, palpitations or headache.
Cơ Chế Tác Dụng : Tecadenoson is a novel selective A1 adenosine receptor agonist that is currently being evaluated for the conversion of paroxysmal supraventricular tachycardia (PSVT) to sinus rhythm. It is being developed by CV Therapeutics, Inc. Tecadenoson selectively stimulates the A1 adenosine receptor. Stimulation of the A1 adenosine receptor slows the conduction of electrical impulses in the AV node of the heart, a region that controls the transmission of electrical impulses from the atria to the ventricles.
Chỉ Định : Investigated for use/treatment in arrhythmia and atrial fibrillation.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04954
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=158795
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10253429
ChemSpider
http://www.chemspider.com/Chemical-Structure.139685.html
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