Tìm theo
TD-5108
Các tên gọi khác (1) :
  • TD 5108
Thuốc Gốc
Small Molecule
TD-5108 is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is being developed by Theravance. TD-5108 was discovered by Theravance through the application of its multivalent drug design in a research program dedicated to finding new treatments for GI motility disorders.
Dược Lực Học : Studies demonstrating the in vivo preclinical profile of TD-5108 showed that the compound has potent 5-HT4 receptor agonist activity by several routes of administration, including oral, providing robust prokinetic activity in the digestive tract of three different animal species, consistent with its highly potent and selective 5-HT4 receptor agonist in vitro profile.
Cơ Chế Tác Dụng : TD-5108 is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is being developed by Theravance. TD-5108 was discovered by Theravance through the application of its multivalent drug design in a research program dedicated to finding new treatments for GI motility disorders. TD-5108 is a potent, highly selective agonist with high intrinsic activity at the 5-HT4 receptor. Relative to other 5-HT receptor types, TD-5108 is > 500-fold selective for binding to the human 5-HT4 receptor. Theravance anticipates that the high degree of selectivity of TD-5108 provides the potential for it to be a better and safer medicine for the treatment of patients with severe constipation and possibly constipation predominant irritable bowel syndrome.
Độc Tính : Overall, the most common adverse events include headache, diarrhea, nausea and vomiting.
Chỉ Định : Investigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05655
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