Tìm theo
Tazobactam
Các tên gọi khác (3) :
  • CL-298741
  • Tazobactam
  • YTR-830H
Thuốc Gốc
Small Molecule
CAS: 89786-04-9
ATC: J01CG02
ĐG : Apotex Inc. , http://www.apotex.com
CTHH: C10H12N4O5S
PTK: 300.291
Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H12N4O5S
Phân tử khối
300.291
Monoisotopic mass
300.052840204
InChI
InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1
InChI Key
InChIKey=LPQZKKCYTLCDGQ-WEDXCCLWSA-N
IUPAC Name
(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Traditional IUPAC Name
tazobactam
SMILES
[H][C@@]12CC(=O)N1[C@@H](C(O)=O)[C@](C)(CN1C=CN=N1)S2(=O)=O
Độ hòa tan
9.59e+00 g/l
logP
-1.4
logS
-1.5
pKa (strongest acidic)
2.86
pKa (Strongest Basic)
0.73
PSA
122.46 Å2
Refractivity
74.82 m3·mol-1
Polarizability
26.22 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
7
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin.
Cơ Chế Tác Dụng : Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases. Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
Chỉ Định : Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01606
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=123630
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508088
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07771
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00660
ChemSpider
http://www.chemspider.com/Chemical-Structure.110216.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173
PharmGKB
http://www.pharmgkb.org/drug/PA164764504
Wikipedia
http://en.wikipedia.org/wiki/Tazobactam
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