Tìm theo
Taliglucerase Alfa
Các tên gọi khác (1) :
  • prGCD
enzymes
Thuốc Gốc
Biotech
CAS: 37228-64-1
ATC: A16AB11
CTHH: C2580H3918N680O727S17
PTK: 56637.9397 g/mol
Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2580H3918N680O727S17
Phân tử khối
56637.9397 g/mol
Độ hòa tan
Soluble in water sodium chloride solutions and ethanol.
Dược Lực Học : Patient's with Type 1 Gaucher disease have a long-term deficiency in the enzyme, glucocerebrosidase. Taliglucerase alfa is a modified form of glucocerebrosidase and is provided to counter this enzyme deficiency, resulting in smaller liver and spleen size, and improved thrombocytopenia and anemia.
Cơ Chế Tác Dụng : Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease. Taliglucerase alfa is different from human glucocerebrosidase by two amino acids at the N terminal and up to 7 amino acids at the C terminal. This recombinant enzyme allows the hydrolysis reaction of glucocerebroside to glucose and ceramide that naturally occurs in healthy individuals.
Dược Động Học :
▧ Absorption :
Taliglucerase alfa is administered IV so absorption is 100%.
▧ Volume of Distribution :
The steady state volume of distribution is between 7.30 to 11.7 L.
▧ Protein binding :
Plasma protein binding was not quantified.
▧ Metabolism :
Metabolism was not determined.
▧ Route of Elimination :
Route of elimination was not determined.
▧ Half Life :
The half life is between 18.9 to 28.7 min.
▧ Clearance :
The systemic clearance was approximately 30 L/hr and 20 L/hr for 30 and 60 units/kg, respectively.
Độc Tính : The most common toxic reaction seen was infusion reactions such as urticaria, arthralgia, headache, and chest pain due to IV administration.
Chỉ Định : For the treatment of adult Type 1 Gaucher disease.
Liều Lượng & Cách Dùng : Injection, powder, for solution - Intravenous - 200 UNITS/VIAL
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : PFIZER
    Sản phẩm biệt dược : Elelyso
  • Công ty : PFIZER
    Sản phẩm biệt dược : UPLYSO
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08876
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D09675
Wikipedia
http://en.wikipedia.org/wiki/Taliglucerase_alfa
RxList
http://www.rxlist.com/elelyso-drug.htm
Drugs.com
http://www.drugs.com/mtm/taliglucerase-alfa.html
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