Taliglucerase Alfa

Các tên gọi khác (1) :

prGCD

enzymes

Thuốc Gốc

Biotech

CAS: 37228-64-1

ATC: A16AB11

CTHH: C₂₅₈₀H₃₉₁₈N₆₈₀O₇₂₇S₁₇

PTK: 56637.9397 g/mol

Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease.

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₂₅₈₀H₃₉₁₈N₆₈₀O₇₂₇S₁₇

Phân tử khối

56637.9397 g/mol

Độ hòa tan

Soluble in water sodium chloride solutions and ethanol.

Dược Lực Học : Patient's with Type 1 Gaucher disease have a long-term deficiency in the enzyme, glucocerebrosidase. Taliglucerase alfa is a modified form of glucocerebrosidase and is provided to counter this enzyme deficiency, resulting in smaller liver and spleen size, and improved thrombocytopenia and anemia.

Cơ Chế Tác Dụng : Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease. Taliglucerase alfa is different from human glucocerebrosidase by two amino acids at the N terminal and up to 7 amino acids at the C terminal. This recombinant enzyme allows the hydrolysis reaction of glucocerebroside to glucose and ceramide that naturally occurs in healthy individuals.

Dược Động Học :

▧ Absorption :
Taliglucerase alfa is administered IV so absorption is 100%.
▧ Volume of Distribution :
The steady state volume of distribution is between 7.30 to 11.7 L.
▧ Protein binding :
Plasma protein binding was not quantified.
▧ Metabolism :
Metabolism was not determined.
▧ Route of Elimination :
Route of elimination was not determined.
▧ Half Life :
The half life is between 18.9 to 28.7 min.
▧ Clearance :
The systemic clearance was approximately 30 L/hr and 20 L/hr for 30 and 60 units/kg, respectively.

Độc Tính : The most common toxic reaction seen was infusion reactions such as urticaria, arthralgia, headache, and chest pain due to IV administration.

Chỉ Định : For the treatment of adult Type 1 Gaucher disease.

Liều Lượng & Cách Dùng : Injection, powder, for solution - Intravenous - 200 UNITS/VIAL

Dữ Kiện Thương Mại

Nhà Sản Xuất

Công ty : PFIZER

Sản phẩm biệt dược : Elelyso
Công ty : PFIZER

Sản phẩm biệt dược : UPLYSO

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB08876

KEGG Drug

http://www.genome.jp/dbget-bin/www_bget?drug:D09675

Wikipedia

http://en.wikipedia.org/wiki/Taliglucerase_alfa

RxList

http://www.rxlist.com/elelyso-drug.htm

Drugs.com

http://www.drugs.com/mtm/taliglucerase-alfa.html

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