Tìm theo
talactoferrin alpha
Thuốc Gốc
Small Molecule
CTHH: C32H44N6O10
PTK: 672.726
Talactoferrin alfa is a novel immunomodulatory 80 kD protein with demonstrated oral anti-tumor properties. Lactoferrin, a protein found in breast milk is developed by Agennix. It increases body’s immune power and also works as a natural antioxidant, helping to control cell and tissue damage caused by oxidation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C32H44N6O10
Phân tử khối
672.726
Monoisotopic mass
672.311891658
InChI
InChI=1S/C32H44N6O10/c1-18(2)12-24(38-29(44)23(33)13-19-4-8-21(40)9-5-19)30(45)34-16-28(43)37-26(17-39)31(46)35-15-27(42)36-25(32(47)48-3)14-20-6-10-22(41)11-7-20/h4-11,18,23-26,39-41H,12-17,33H2,1-3H3,(H,34,45)(H,35,46)(H,36,42)(H,37,43)(H,38,44)/t23-,24-,25-,26-/m0/s1
InChI Key
InChIKey=XKVDFADVPPHGJR-CQJMVLFOSA-N
IUPAC Name
methyl (2S)-2-{2-[(2S)-2-{2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]acetamido}-3-hydroxypropanamido]acetamido}-3-(4-hydroxyphenyl)propanoate
Traditional IUPAC Name
methyl (2S)-2-{2-[(2S)-2-{2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]acetamido}-3-hydroxypropanamido]acetamido}-3-(4-hydroxyphenyl)propanoate
SMILES
COC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1
Độ hòa tan
5.37e-02 g/l
logP
-1.6
logS
-4.1
pKa (strongest acidic)
9.21
pKa (Strongest Basic)
7.72
PSA
258.51 Å2
Refractivity
171.18 m3·mol-1
Polarizability
68.36 Å3
Rotatable Bond Count
19
H Bond Acceptor Count
10
H Bond Donor Count
9
Physiological Charge
1
Number of Rings
2
Bioavailability
0
Cơ Chế Tác Dụng : Talactoferrin alfa is a novel immunomodulatory 80 kD protein with demonstrated oral anti-tumor properties. Lactoferrin, a protein found in breast milk is developed by Agennix. It increases body’s immune power and also works as a natural antioxidant, helping to control cell and tissue damage caused by oxidation. Oral talactoferrin stimulated the production of the immunostimulatory cytokine IL-18 in mice, increasing IL-18 levels both in the gut and in systemic circulation. Oral talactoferrin was also shown to stimulate the activity of NK cells and to increase the production and activity of key circulating immune cells.
Chỉ Định : Investigated for use/treatment in adverse effects (chemotherapy), cancer/tumors (unspecified), diabetic foot ulcers, lung cancer, solid tumors, and ulcers.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05426
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=192716
ChemSpider
http://www.chemspider.com/Chemical-Structure.167235.html
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