Tìm theo
Tagatose
Các tên gọi khác (5 ) :
  • D-lyxo-hex-2-ulose
  • D-tag
  • D-Tagatose
  • DL-tagatose
  • lyxo-2-hexulose
iron chelating agents
Thuốc Gốc
Small Molecule
CAS: 17598-81-1
CTHH: C6H12O6
PTK: 180.1559
Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is often found in dairy products, and is very similar in texture to sucrose (table sugar) and is 92% as sweet, but with only 38% of the calories. It is approved as a food additive as a low calorie sweetener. Additionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H12O6
Phân tử khối
180.1559
Monoisotopic mass
180.063388116
InChI
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5+,6-/m1/s1
InChI Key
InChIKey=BJHIKXHVCXFQLS-PQLUHFTBSA-N
IUPAC Name
(3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one
Traditional IUPAC Name
tagatose
SMILES
OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO
Độ tan chảy
133-135 °C
Độ hòa tan
3.99e+02 g/l
logP
-3.3
logS
0.35
pKa (strongest acidic)
9.48
pKa (Strongest Basic)
-3
PSA
118.22 Å2
Refractivity
37.56 m3·mol-1
Polarizability
16.44 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
6
H Bond Donor Count
5
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Oral tagatose significantly blunts the rise in plasma glucose seen after oral glucose in patients with diabetes mellitus in a dose-dependent manner without significantly affecting insulin levels. The minimal elevation of plasma tagatose levels in normal patients and the adverse gastrointestinal effects seen following larger doses of tagatose support poor absorption of this hexose and suggest that tagatose may act by attenuating glucose absorption in the intestine.
Cơ Chế Tác Dụng : Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is often found in dairy products, and is very similar in texture to sucrose (table sugar) and is 92% as sweet, but with only 38% of the calories. It is approved as a food additive as a low calorie sweetener. Additionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes. he steps in the metabolism of tagatose are identical to those for fructose or fruit sugar but tagatose is incompletely absorbed. Only 15-20 percent of tagatose is absorbed in the small intestine. The major part of ingested tagatose is fermented in the colon by indigenous microflora, resulting in the production of short-chain fatty acids. The short chain fatty acids are absorbed almost completely and metabolized.
Dược Động Học :
▧ Absorption :
Only 15-20 percent of tagatose is absorbed in the small intestine.
▧ Metabolism :
Since it is metabolized differently from sucrose, tagatose has a minimal effect on blood glucose and insulin levels.
Chỉ Định : Intended for use as a therapeutic adjunct in the treatment of type II diabetes.
Liều Lượng & Cách Dùng : Granule - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Naturlose
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04936
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=92092
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10225176
ChemSpider
http://www.chemspider.com/Chemical-Structure.83142.html
Wikipedia
http://en.wikipedia.org/wiki/Tagatose
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