Tìm theo
TA-NIC
Các tên gọi khác (3) :
  • Cholaic acid
  • Cholyltaurine
  • Taurocholate
Thuốc Gốc
Biotech
CTHH: C26H45NO7S
PTK: 515.7030
TA-NIC is a novel and proprietary vaccine in development as an aid to quitting smoking in motivated patients. TA-NIC is an immunotherapeutic vaccine similar in concept to TA-CD, designed to raise anti-nicotine antibodies. The antibodies bind to nicotine molecules in the patient's blood stream, reducing the rate and quantity of nicotine entry into the brain and thus reducing the positive reinforcement and addiction associated with nicotine and cigarette smoking. It is expected that the reduction of the positive reinforcement will in turn reduce the desire to smoke or use other tobacco products.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H45NO7S
Phân tử khối
515.7030
Dược Lực Học : Raises anti-nicotine antibodies. The antibodies bind to nicotine molecules in the patient's blood stream, reducing the rate and quantity of nicotine entry into the brain and thus reducing the positive reinforcement and addiction associated with nicotine and cigarette smoking. It is expected that the reduction of the positive reinforcement will in turn reduce the desire to smoke or use other tobacco products. Preliminary trials have supported this supposition.
Cơ Chế Tác Dụng : TA-NIC is a novel and proprietary vaccine in development as an aid to quitting smoking in motivated patients. TA-NIC is an immunotherapeutic vaccine similar in concept to TA-CD, designed to raise anti-nicotine antibodies. The antibodies bind to nicotine molecules in the patient's blood stream, reducing the rate and quantity of nicotine entry into the brain and thus reducing the positive reinforcement and addiction associated with nicotine and cigarette smoking. It is expected that the reduction of the positive reinforcement will in turn reduce the desire to smoke or use other tobacco products. Reduces nicotine entry into the brain and thus the positive reinforcement associated with smoking.
Dược Động Học :

▧ Protein binding :
TA-NIC consists of nicotine conjugated to the carrier protein rCTB and an aluminium adjuvant.
Độc Tính : Appears to be well-tolerated.
Chỉ Định : Investigated for use/treatment in tobacco dependence.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05445
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6675
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