Tìm theo
Suramin
Các tên gọi khác (6 ) :
  • 8,8'-[CARBONYLBIS[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid
  • Belganyl
  • Naganol
  • Naphuride
  • Suramin
  • Suramine
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 145-63-1
ATC: P01CX02
CTHH: C51H40N6O23S6
PTK: 1297.28
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin®.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C51H40N6O23S6
Phân tử khối
1297.28
Monoisotopic mass
1296.046905756
InChI
InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
InChI Key
InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N
IUPAC Name
8-[(4-methyl-3-{[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzene]amido}benzene)amido]naphthalene-1,3,5-trisulfonic acid
Traditional IUPAC Name
8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonic acid
SMILES
CC1=C(NC(=O)C2=CC(NC(=O)NC3=CC=CC(=C3)C(=O)NC3=C(C)C=CC(=C3)C(=O)NC3=C4C(C=C(C=C4S(O)(=O)=O)S(O)(=O)=O)=C(C=C3)S(O)(=O)=O)=CC=C2)C=C(C=C1)C(=O)NC1=C2C(C=C(C=C2S(O)(=O)=O)S(O)(=O)=O)=C(C=C1)S(O)(=O)=O
Độ hòa tan
8.72e-03 g/l
logP
5.58
logS
-5.2
pKa (strongest acidic)
-3.5
PSA
483.75 Å2
Refractivity
314.9 m3·mol-1
Polarizability
120.22 Å3
Rotatable Bond Count
16
H Bond Acceptor Count
23
H Bond Donor Count
12
Physiological Charge
-6
Number of Rings
8
Bioavailability
0
MDDR-Like Rule
true
Cơ Chế Tác Dụng : A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin®. The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Suramin's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal. It may also act as an antagonist of P2 receptors and as an agonist of Ryanodine receptors. It also can inhibit follicle-stimulating hormone receptors.
Dược Động Học :
▧ Absorption :
Poorly absorbed from the gastrointestinal tract.
▧ Protein binding :
Approximately 99.7%
▧ Metabolism :
Little or no metabolism
▧ Half Life :
Approximately 36 to 60 days
Chỉ Định : For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
Liều Lượng & Cách Dùng : Injection, powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : 309 Fourneau
  • Công ty :
    Sản phẩm biệt dược : Antrypol
  • Công ty :
    Sản phẩm biệt dược : Bayer 205
  • Công ty :
    Sản phẩm biệt dược : Belganyl
  • Công ty : Bayer
    Sản phẩm biệt dược : Germanin
  • Công ty :
    Sản phẩm biệt dược : Moranyl
  • Công ty :
    Sản phẩm biệt dược : Naganin
  • Công ty :
    Sản phẩm biệt dược : Naganine
  • Công ty :
    Sản phẩm biệt dược : Naganol
  • Công ty :
    Sản phẩm biệt dược : Naphuride
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04786
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5361
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507013
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07974
ChemSpider
http://www.chemspider.com/Chemical-Structure.5168.html
PharmGKB
http://www.pharmgkb.org/drug/PA10292
Wikipedia
http://en.wikipedia.org/wiki/Suramin
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