Tìm theo
Suprofen
Các tên gọi khác (13 ) :
  • (+-)-2-(P-(2-Thenoyl)phenyl)propionic acid
  • 2-(4-(2-Thenoyl)phenyl)propionsaeure
  • 2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid
  • 4-(2-Thenoyl)hydratropsaeure
  • alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid
  • P-2-Thenoylhydratropic acid
  • PROFENAL
  • Suprofen
  • Suprofène
  • Suprofene
  • Suprofeno
  • Suprofenum
  • SUTOPROFEN
anti inflammatory agents non steroidal, cyclooxygenase inhibitors
Thuốc Gốc
Small Molecule
CAS: 40828-46-4
ATC: M01AE07
CTHH: C14H12O3S
PTK: 260.308
An ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H12O3S
Phân tử khối
260.308
Monoisotopic mass
260.05071494
InChI
InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
InChI Key
InChIKey=MDKGKXOCJGEUJW-UHFFFAOYSA-N
IUPAC Name
2-{4-[(thiophen-2-yl)carbonyl]phenyl}propanoic acid
Traditional IUPAC Name
suprofen
SMILES
CC(C(O)=O)C1=CC=C(C=C1)C(=O)C1=CC=CS1
Độ tan chảy
124.3 °C
Độ hòa tan
limited solubility
logP
2.2
logS
-3.8
pKa (strongest acidic)
4.01
pKa (Strongest Basic)
-7.8
PSA
54.37 Å2
Refractivity
69.41 m3·mol-1
Polarizability
26.84 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
3.91
Dược Lực Học : Suprofen is a non-steroidal anti-inflammatory analgesic and antipyretic. Ophthalmic anti-inflammatory medicines are used in the eye to lessen problems that can occur during or after some kinds of eye surgery. Sometimes, the pupil of the eye gets smaller during an operation (pupil constriction), making it more difficult for the surgeon to reach some areas of the eye. Suprofen is used to help prevent this.
Cơ Chế Tác Dụng : An ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States. Suprofen binds to the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes, preventing the synthesis of prostaglandins and reducing the inflammatory response. Cyclooxygenase catalyses the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation. The overall result is a reduction in pain and inflammation in the eyes and the prevention of pupil constriction during surgery. Normally trauma to the anterior segment of the eye (especially the iris) increases endogenous prostaglandin synthesis which leads to constriction of the iris sphincter.
Dược Động Học :

▧ Protein binding :
20%
▧ Metabolism :
Primarily hepatic (mainly via cytochrome P450 isozyme 2C9).
Độc Tính : Symptoms of overdose include bleeding in the eye or redness or swelling of the eye or the eyelid, blurred vision or other change in vision, fever or chills, itching or tearing, nausea or vomiting, pain, sensitivity to light, shortness of breath, sticky or matted eyelashes, swelling of face, throbbing pain, tightness in chest, troubled breathing, and wheezing.
Chỉ Định : Used as eye drops to inhibit the miosis (pupil constriction) that may occur during ocular surgery.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00870
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5359
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508210
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07320
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00452
ChemSpider
http://www.chemspider.com/Chemical-Structure.5166.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090676
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0065-0348-25
PharmGKB
http://www.pharmgkb.org/drug/PA451569
Wikipedia
http://en.wikipedia.org/wiki/Suprofen
Drugs.com
http://www.drugs.com/mtm/suprofen-ophthalmic.html
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