Tìm theo
Sulpiride
Các tên gọi khác (11 ) :
  • (+-)-Sulpiride
  • 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide
  • Levosulpirida
  • Levosulpiride
  • Levosulpiridum
  • N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide
  • N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-O-anisamide
  • Sulpirid
  • Sulpirida
  • Sulpiridum
  • Sulpyrid
Thuốc điều trị về tâm thần
Thuốc Gốc
Small Molecule
CAS: 15676-16-1
ATC: N05AL01, N05AL07
CTHH: C15H23N3O4S
PTK: 341.426
A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H23N3O4S
Phân tử khối
341.426
Monoisotopic mass
341.140926929
InChI
InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
InChI Key
InChIKey=BGRJTUBHPOOWDU-UHFFFAOYSA-N
IUPAC Name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Traditional IUPAC Name
sulpiride
SMILES
CCN1CCCC1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O
Độ tan chảy
178 dec °C
Độ hòa tan
2280 mg/L
logP
0.57
logS
-2.8
pKa (strongest acidic)
10.24
pKa (Strongest Basic)
8.39
PSA
101.73 Å2
Refractivity
88.63 m3·mol-1
Polarizability
36.18 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
caco2 Permeability
-6.16
pKa
9.12
Dược Lực Học : Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride.
Cơ Chế Tác Dụng : A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed) In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
Dược Động Học :
▧ Absorption :
Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
▧ Half Life :
6 to 8 hours
Độc Tính : Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
Chỉ Định : Sulpiride is indicated for the treatment of schizophrenia.
Liều Lượng & Cách Dùng : Solution - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Bosnyl
  • Công ty :
    Sản phẩm biệt dược : Dogmatil
  • Công ty :
    Sản phẩm biệt dược : Dogmatyl
  • Công ty :
    Sản phẩm biệt dược : Dolmatil
  • Công ty :
    Sản phẩm biệt dược : Eglonyl
  • Công ty :
    Sản phẩm biệt dược : Espiride
  • Công ty :
    Sản phẩm biệt dược : Meresa
  • Công ty :
    Sản phẩm biệt dược : Modal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00391
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5355
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504855
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01226
ChemSpider
http://www.chemspider.com/Chemical-Structure.5162.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11638
PharmGKB
http://www.pharmgkb.org/drug/PA164745485
Wikipedia
http://en.wikipedia.org/wiki/Sulpiride
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