Tìm theo
Sulfoxone
Các tên gọi khác (1) :
  • Sulfoxone
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 144-75-2
CTHH: C14H16N2O6S3
PTK: 404.482
Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H16N2O6S3
Phân tử khối
404.482
Monoisotopic mass
404.017048324
InChI
InChI=1S/C14H16N2O6S3/c17-23(18)9-15-11-1-5-13(6-2-11)25(21,22)14-7-3-12(4-8-14)16-10-24(19)20/h1-8,15-16H,9-10H2,(H,17,18)(H,19,20)
InChI Key
InChIKey=NEDPPCHNEOMTJV-UHFFFAOYSA-N
IUPAC Name
{[4-({4-[(sulfinomethyl)amino]benzene}sulfonyl)phenyl]amino}methanesulfinic acid
Traditional IUPAC Name
[(4-{4-[(sulfinomethyl)amino]benzenesulfonyl}phenyl)amino]methanesulfinic acid
SMILES
OS(=O)CNC1=CC=C(C=C1)S(=O)(=O)C1=CC=C(NCS(O)=O)C=C1
Độ hòa tan
2.63e+00 g/l
logP
-2.8
logS
-2.2
pKa (strongest acidic)
-1.5
pKa (Strongest Basic)
-0.056
PSA
132.8 Å2
Refractivity
96.95 m3·mol-1
Polarizability
38.81 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
8
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Sulfoxone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Cơ Chế Tác Dụng : Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis. Sulfoxone is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal substrate for the enzyme, para-aminobenzoic acid (PABA) cannot bind as usual. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dược Động Học :
▧ Absorption :
Rapidly absorbed.
▧ Protein binding :
69%
▧ Metabolism :
Hepatic.
▧ Half Life :
3-8 hours
Độc Tính : Oral, rat LD50: 7000 mg/kg
Chỉ Định : For the treatment of leprosy and dermatitis herpetiformis
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01145
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5351
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507392
ChemSpider
http://www.chemspider.com/Chemical-Structure.5158.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776911
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