Tìm theo
Sulfathiazole
Các tên gọi khác (14 ) :
  • 2-(P-Aminobenzenesulfonamido)thiazole
  • 2-(P-Aminobenzenesulphonamido)thiazole
  • 2-(Sulfanilylamino)thiazole
  • 2-Sulfanilamidothiazol
  • 2-Sulfanilamidothiazole
  • 2-Sulfonamidothiazole
  • 4-Amino-N-2-thiazolylbenzenesulfonamide
  • N(1)-2-Thiazolylsulfanilamide
  • N1-2-Thiazolylsulfanilamide
  • Sulfanilamidothiazole
  • Sulfathiazol
  • Sulfathiazolum
  • Sulfatiazol
  • Sulphathiazole
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 72-14-0
ATC: J01EB07, D06BA02
CTHH: C9H9N3O2S2
PTK: 255.317
Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H9N3O2S2
Phân tử khối
255.317
Monoisotopic mass
255.013617927
InChI
InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
InChI Key
InChIKey=JNMRHUJNCSQMMB-UHFFFAOYSA-N
IUPAC Name
4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
Traditional IUPAC Name
sulfathiazole
SMILES
NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1
Độ tan chảy
189 °C
Độ hòa tan
373 mg/L (at 25 °C)
logP
0.05
logS
-2.4
pKa (strongest acidic)
6.93
pKa (Strongest Basic)
2.04
PSA
85.08 Å2
Refractivity
62.27 m3·mol-1
Polarizability
23.96 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
7.2
Dược Động Học :

▧ Metabolism :
Metabolism of sulfonamide drugs in animals includes conjugation at the N4-position (acetyl, sulfate, glucuronic acid, and glucose), conjugation at the N1-position (sulfate and glucuronic acid), removal of the p-amino group (formation of the desamino metabolite), ring hydroxylation, and conjugation of the ring hydroxylation products. Dietary nitrite enhances the production of the desamino metabolite of sulfathiazole. The intermediate leading to the desamino metabolite of sulfamethazine is weakly mutagenic in the Ames test (Nelson et al., 1987; Paulson et al., 1987).
Độc Tính : Acute oral toxicity (LD50): 4500 mg/kg [Mouse].
Chỉ Định : Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Galen
    Sản phẩm biệt dược : Norsulfazolum
  • Công ty : Fecofar
    Sản phẩm biệt dược : Sulfatiazol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06147
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11169
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01047
PharmGKB
http://www.pharmgkb.org/drug/PA165958356
Wikipedia
http://en.wikipedia.org/wiki/Sulfathiazole
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