Tìm theo
Sulfapyridine
Các tên gọi khác (19 ) :
  • 2-(P-Aminobenzenesulphonamido)pyridine
  • 2-Sulfanilamidopyridin
  • 2-Sulfanilamidopyridine
  • 2-Sulfanilylaminopyridine
  • 2-Sulfapyridine
  • 4-(2-Pyridinylsulfonyl)aniline
  • 4-[(2-Pyridylamino)sulfonyl]aniline
  • 4-Amino-N-pyridin-2-yl-benzenesulfonamide
  • 4-Amino-N,2-pyridinylbenzenesulfonamide
  • N-2-Pyridylsulfanilamide
  • N(1)-2-Pyridylsulfanilamide
  • N(1)-Pyridylsulfanilamide
  • Solfapiridina
  • Streptosilpyridine
  • Sulfapiridina
  • Sulfapyridin
  • Sulfapyridine
  • Sulfapyridinum
  • Sulphapyridine
dermatologic agents, anti infective agents, sulfonamides
Thuốc Gốc
Small Molecule
CAS: 144-83-2
ATC: J01EB04
ĐG : Amend
CTHH: C11H11N3O2S
PTK: 249.289
Antibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H11N3O2S
Phân tử khối
249.289
Monoisotopic mass
249.057197301
InChI
InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
InChI Key
InChIKey=GECHUMIMRBOMGK-UHFFFAOYSA-N
IUPAC Name
4-amino-N-(pyridin-2-yl)benzene-1-sulfonamide
Traditional IUPAC Name
sulfapyridine
SMILES
NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=N1
Độ tan chảy
192 °C
Độ hòa tan
268 mg/L (at 25 °C)
logP
0.35
logS
-2.7
pKa (strongest acidic)
6.24
pKa (Strongest Basic)
2.63
PSA
85.08 Å2
Refractivity
65.75 m3·mol-1
Polarizability
24.97 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
8.43
Dược Lực Học : Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Cơ Chế Tác Dụng : Antibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed. Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.
Dược Động Học :
▧ Absorption :
Approximately 60-80%
▧ Protein binding :
Approximately 50% bound to plasma proteins.
▧ Metabolism :
Hepatic.
▧ Half Life :
6-14 hours.
Độc Tính : LD50 is 15800 mg/kg (orally in rats).
Chỉ Định : For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Tương Tác Thuốc :
  • Chlorpropamide Sulfonamide/sulfonylurea: possible hypoglycemia
  • Methotrexate The sulfamide increases the toxicity of methotrexate
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Sulfapyridine powder
    Giá bán buôn : USD >0.13
    Đơn vị tính : g
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00891
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5336
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506991
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02434
ChemSpider
http://www.chemspider.com/Chemical-Structure.5145.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225845
PharmGKB
http://www.pharmgkb.org/drug/PA164779050
Wikipedia
http://en.wikipedia.org/wiki/Sulfapyridine
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