Tìm theo
Sulfaphenazole
Các tên gọi khác (11 ) :
  • 1-Phenyl-5-sulfanilamidopyrazole
  • 3-(P-Aminobenzenesulfonamido)-2-phenylpyrazole
  • 5-Sulfanilamido-1-phenylpyrazole
  • N'-(1-phenylpyrazol-5-yl)sulfanilamide
  • N(1)-(1-Phenylpyrazol-5-yl)sulfanilamide
  • Sulfabid
  • Sulfafenazol
  • Sulfafenazolo
  • Sulfaphenazol
  • Sulfaphenazolum
  • Sulphaphenazole
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 526-08-9
ATC: S01AB05, J01ED08
CTHH: C15H14N4O2S
PTK: 314.362
Sulfaphenazole is a sulfonamide antibacterial.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H14N4O2S
Phân tử khối
314.362
Monoisotopic mass
314.083746402
InChI
InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
InChI Key
InChIKey=QWCJHSGMANYXCW-UHFFFAOYSA-N
IUPAC Name
4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzene-1-sulfonamide
Traditional IUPAC Name
sulfaphenazole
SMILES
NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=NN1C1=CC=CC=C1
Độ tan chảy
181 °C
Độ hòa tan
1500 mg/L (at 25 °C)
logP
1.52
logS
-3
pKa (strongest acidic)
6.9
pKa (Strongest Basic)
2.43
PSA
90.01 Å2
Refractivity
85.21 m3·mol-1
Polarizability
31.82 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Sulfaphenazole is a sulfonamide antibacterial. Sulfaphenazole is a sulfonamide antibacterial. In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase (DHPS), an enzyme involved in folate synthesis. As such, the microorganism will be "starved" of folate and die.
Dược Động Học :

▧ Metabolism :
Hepatic.
Chỉ Định : For the treatment bacterial infections.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Sulfabid
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06729
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5335
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443275
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01954
ChemSpider
http://www.chemspider.com/Chemical-Structure.5144.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090677
PharmGKB
http://www.pharmgkb.org/drug/PA130231310
Wikipedia
http://en.wikipedia.org/wiki/Sulfaphenazole
Drugs.com
http://www.drugs.com/international/sulfabid.html
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