Tìm theo
Sulfamethizole
Các tên gọi khác (7 ) :
  • Rufol
  • Sulfamethizol
  • Sulfaméthizol
  • Sulfamethizole
  • Sulfamethizolum
  • Sulfamethylthiadiazole
  • Sulfametizol
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 144-82-1
ATC: B05CA04, D06BA04, J01EB02, S01AB01
ĐG : Prescript Pharmaceuticals , http://www.prescript.net
CTHH: C9H10N4O2S2
PTK: 270.331
A sulfathiazole antibacterial agent. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H10N4O2S2
Phân tử khối
270.331
Monoisotopic mass
270.024516964
InChI
InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)
InChI Key
InChIKey=VACCAVUAMIDAGB-UHFFFAOYSA-N
IUPAC Name
4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide
Traditional IUPAC Name
sulfamethizole
SMILES
CC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1
Độ tan chảy
208 °C
Độ hòa tan
1050 mg/L (at 37 °C)
logP
0.54
logS
-2.41
pKa (strongest acidic)
6.71
pKa (Strongest Basic)
1.95
PSA
97.97 Å2
Refractivity
66.84 m3·mol-1
Polarizability
26.26 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Cơ Chế Tác Dụng : A sulfathiazole antibacterial agent. [PubChem] Sulfamethizole is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dược Động Học :
▧ Absorption :
Rapidly absorbed.
▧ Protein binding :
98-99%
▧ Metabolism :
Hepatic.
▧ Half Life :
3-8 hours
Chỉ Định : For the treatment of urinary tract infection
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Recip
    Sản phẩm biệt dược : Lucosil
  • Công ty : Urgo
    Sản phẩm biệt dược : Rufol
  • Công ty :
    Sản phẩm biệt dược : Thiosulfil
  • Công ty :
    Sản phẩm biệt dược : Thiosulfil Forte
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00576
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5328
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508656
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08050
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00870
ChemSpider
http://www.chemspider.com/Chemical-Structure.5137.html
PharmGKB
http://www.pharmgkb.org/drug/PA164781307
Wikipedia
http://en.wikipedia.org/wiki/Sulfamethizole
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