Tìm theo
Sulfamerazine
Các tên gọi khác (12 ) :
  • (P-Aminobenzolsulfonyl)-2-amino-4-methylpyrimidin
  • 2-(4-Aminobenzenesulfonamido)-4-methylpyrimidine
  • 2-(P-Aminobenzolsulfonamido)-4-methylpyrimidine
  • 2-(Sulfanilamido)-4-methylpyrimidine
  • 2-Sulfa-4-methylpyrimidine
  • 4-Amino-N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide
  • N-(4-Methyl-2-pyrimidyl)sulfanilamide
  • N(1)-(4-Methyl-2-pyrimidinyl)sulfanilamide
  • Sulfamerazina
  • Sulfamerazinum
  • Sulfamethyldiazine
  • Sulphamerazine
sulfonamides
Thuốc Gốc
Small Molecule
CAS: 127-79-7
ATC: J01ED07, D06BA06
CTHH: C11H12N4O2S
PTK: 264.304
A sulfanilamide that is used as an antibacterial agent. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H12N4O2S
Phân tử khối
264.304
Monoisotopic mass
264.068096338
InChI
InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
InChI Key
InChIKey=QPPBRPIAZZHUNT-UHFFFAOYSA-N
IUPAC Name
4-amino-N-(4-methylpyrimidin-2-yl)benzene-1-sulfonamide
Traditional IUPAC Name
sulfamerazine
SMILES
CC1=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC=C1
Độ tan chảy
236 °C
Độ hòa tan
202 mg/L (at 20 °C)
logP
0.14
logS
-2.9
pKa (strongest acidic)
6.99
pKa (Strongest Basic)
2.01
PSA
97.97 Å2
Refractivity
68.79 m3·mol-1
Polarizability
26.51 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase (DHPS), an enzyme involved in folate synthesis in bacteria.
Cơ Chế Tác Dụng : A sulfanilamide that is used as an antibacterial agent. [PubChem] Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
Độc Tính : Sulfamerazine may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.
Chỉ Định : A sulfanilamide that is used as an antibacterial agent. It can be used to treat bronchitis, prostatitis and urinary tract infections.
Tương Tác Thuốc :
  • Chlorpropamide Sulfonamide/sulfonylurea: possible hypoglycemia
  • Methotrexate The sulfamide increases the toxicity of methotrexate
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01581
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5325
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505036
ChemSpider
http://www.chemspider.com/Chemical-Structure.5134.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776842
Wikipedia
http://en.wikipedia.org/wiki/Sulfamerazine
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