Tìm theo
Sulfadimethoxine
Các tên gọi khác (13 ) :
  • 2,4-dimethoxy-6-sulfanilamido-1,3-diazine
  • 2,6-Dimethoxy-4-(P-aminobenzenesulfonamido)pyrimidine
  • 2,6-Dimethoxy-4-sulfanilamidopyrimidine
  • 4-amino-N-(2,6-Dimethoxy-4-pyrimidinyl)benzenesulfonamide
  • 6-Sulfanilamido-2,4-dimethoxypyrimidine
  • Abcid (tn)
  • Agribon (tn)
  • N(1)-(2,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
  • Sulfadimethoxine
  • Sulfadimethoxinum
  • Sulfadimethoxydiazine
  • Sulfadimetoxina
  • Sulphadimethoxine
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 122-11-2
ATC: J01ED01
CTHH: C12H14N4O4S
PTK: 310.329
Sulfadimethoxine is a sulfonamide antibiotic. Sulfadimethoxine is used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some countries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. Sulfadimethoxine is approved in Russia for use in humans, including children, and has been successfully used there for more than 35 years. It is widely available in Russia as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H14N4O4S
Phân tử khối
310.329
Monoisotopic mass
310.073575646
InChI
InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI Key
InChIKey=ZZORFUFYDOWNEF-UHFFFAOYSA-N
IUPAC Name
4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide
Traditional IUPAC Name
sulfadimethoxine
SMILES
COC1=NC(OC)=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=C1
Độ tan chảy
203.5 °C
Độ hòa tan
343 mg/L
logP
1.63
logS
-3
pKa (strongest acidic)
6.91
pKa (Strongest Basic)
1.95
PSA
116.43 Å2
Refractivity
77.75 m3·mol-1
Polarizability
29.6 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
7
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Sulfadimethoxine has been shown to be effective against streptococci, klebsiella, proteus, shigella, staphylococci, escherichia, and salmonella.
Chỉ Định : For use in the treatment of infections.
Tương Tác Thuốc :
  • Methotrexate The sulfamide increases the toxicity of methotrexate
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06150
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01142
PharmGKB
http://www.pharmgkb.org/drug/PA165958357
Wikipedia
http://en.wikipedia.org/wiki/Sulfadimethoxine
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