Tìm theo
Succinylcholine
Các tên gọi khác (9 ) :
  • 2,2'-[(1,4-DIOXOBUTANE-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
  • Dicholine succinate
  • Succinic acid, diester with choline
  • Succinocholine
  • Succinoylcholine
  • Succinylbischoline
  • Succinylcholine
  • Succinyldicholine
  • Suxamethonium
neuromuscular depolarizing agents, muscle relaxant skeletal
Thuốc Gốc
Small Molecule
CAS: 306-40-1
ATC: M03AB01
ĐG : Hospira Inc. , http://www.hospira.com
CTHH: C14H30N2O4
PTK: 290.399
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H30N2O4
Phân tử khối
290.399
Monoisotopic mass
290.220557458
InChI
InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
InChI Key
InChIKey=AXOIZCJOOAYSMI-UHFFFAOYSA-N
IUPAC Name
trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium
Traditional IUPAC Name
succinylcholine
SMILES
C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
Độ hòa tan
7.57e-04 g/l
logP
-8.4
logS
-5.7
pKa (Strongest Basic)
-6.8
PSA
52.6 Å2
Refractivity
100.94 m3·mol-1
Polarizability
33.15 Å3
Rotatable Bond Count
11
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
2
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Succinylcholine has no direct action on the uterus or other smooth muscle structures.
Cơ Chế Tác Dụng : A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. [PubChem] The mechanism of action of Succinylcholine involves what appears to be a "persistent" depolarization of the neuromuscular junction. This depolarization is caused by Succinylcholine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization.
Dược Động Học :

▧ Metabolism :
By pseudocholinesterase, to succinylmonocholine and choline.
▧ Route of Elimination :
About 10% of the drug is excreted unchanged in the urine.
Chỉ Định : Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
Tương Tác Thuốc :
  • Amikacin The agent increases the effect of muscle relaxant
  • Clindamycin The agent increases the effect of muscle relaxant
  • Cyclophosphamide Cyclophosphamide may increase the effect of succinylcholine.
  • Dihydrocodeine May enhance the bradycardic effect of opioid analgesics. It is recommended to monitor therapy.
  • Echothiophate Echothiophate iodide may increase the effect of succinylcholine.
  • Gentamicin The agent increases the effect of muscle relaxant
  • Lincomycin The agent increases the effect of muscle relaxant
  • Netilmicin The agent increases the effect of muscle relaxant
  • Piperacillin The agent increases the effect of the muscle relaxant
  • Quinidine The quinine derivative increases the effect of the muscle relaxant
  • Quinine The quinine derivative increases the effect of the muscle relaxant
  • Tacrine Tacrine may increase the effects of Succinylcholine. Monitor Succinylcholine therapy for increased effects.
  • Tobramycin The agent increases the effect of the muscle relaxant
Liều Lượng & Cách Dùng : Liquid - Intravenous
Solution - Intravenous
Solution - Intravenous
Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Anectine
  • Công ty :
    Sản phẩm biệt dược : Quelicin
  • Công ty :
    Sản phẩm biệt dược : Scoline
  • Công ty :
    Sản phẩm biệt dược : Sucostrin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00202
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5314
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506023
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07546
ChemSpider
http://www.chemspider.com/Chemical-Structure.5123.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0781-3009-95
PharmGKB
http://www.pharmgkb.org/drug/PA451522
Wikipedia
http://en.wikipedia.org/wiki/Succinylcholine
RxList
http://www.rxlist.com/cgi/generic2/succinyl.htm
Drugs.com
http://www.drugs.com/cdi/succinylcholine.html
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