Tìm theo
Succimer
Các tên gọi khác (5 ) :
  • Chemet
  • Dimercaptosuccinic acid
  • DMSA
  • Meso-2,3-dimercaptosuccinic acid
  • Meso-dimercaptosuccinic acid
chelating agents, antidotes
Thuốc Gốc
Small Molecule
CAS: 304-55-2
ĐG : GE Healthcare Inc. , http://www.gehealthcare.com
CTHH: C4H6O4S2
PTK: 182.218
A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C4H6O4S2
Phân tử khối
182.218
Monoisotopic mass
181.97075006
InChI
InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)
InChI Key
InChIKey=ACTRVOBWPAIOHC-UHFFFAOYSA-N
IUPAC Name
2,3-disulfanylbutanedioic acid
Traditional IUPAC Name
succimer
SMILES
OC(=O)C(S)C(S)C(O)=O
Độ tan chảy
193 °C
Độ hòa tan
2.43e+00 g/l
logP
-0.3
logS
-1.9
pKa (strongest acidic)
3.37
PSA
74.6 Å2
Refractivity
38.47 m3·mol-1
Polarizability
15.47 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Succimer is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Succimer is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.
Cơ Chế Tác Dụng : A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. [PubChem] Succimer is a heavy metal chelator. It binds with high specificity to ions of lead in the blood to form a water-soluble complex that is subsequently excreted by the kidneys. Succimer can also chelate mercury, cadmium, and arsenic in this manner.
Dược Động Học :
▧ Absorption :
Rapid but variable.
▧ Metabolism :
Chemical analysis of succimer and its metabolites (primarily mixed disulfides of L-cysteine) in the urine showed that succimer was rapidly and extensively metabolized however the specific site of biotransformation is not known.
▧ Route of Elimination :
Unabsorbed drug is excreted primarily in feces and absorbed drug is excreted primarily in the urine as metabolites.
▧ Half Life :
48 hours
Độc Tính : Oral LD50 in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.
Chỉ Định : For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
Liều Lượng & Cách Dùng : Capsule, coated pellets - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Chemet 100 mg capsule
    Giá bán buôn : USD >8.6
    Đơn vị tính : capsule
  • Biệt dược thương mại : Dmsa powder
    Giá bán buôn : USD >15.61
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty : Lundbeck LLC
    Sản phẩm biệt dược : CHEMET
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00566
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9354
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504680
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07598
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00572
ChemSpider
http://www.chemspider.com/Chemical-Structure.8988.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232640
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/17156-525-01
PharmGKB
http://www.pharmgkb.org/drug/PA451521
Wikipedia
http://en.wikipedia.org/wiki/Succimer
RxList
http://www.rxlist.com/chemet-drug.htm
Drugs.com
http://www.drugs.com/cdi/succimer.html
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