Tìm theo
Streptolydigin
Các tên gọi khác (1) :
  • Portamycin
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 7229-50-7
CTHH: C32H44N2O9
PTK: 600.6998
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C32H44N2O9
Phân tử khối
600.6998
Monoisotopic mass
600.304681016
InChI
InChI=1S/C32H44N2O9/c1-16(14-17(2)28-18(3)23-12-13-32(15-40-32)31(6,42-23)43-28)8-9-22(36)25-27(37)26(19(4)29(38)33-7)34(30(25)39)24-11-10-21(35)20(5)41-24/h8-9,12-14,17-21,23-24,26,28,35,39H,10-11,15H2,1-7H3,(H,33,38)/b9-8+,16-14+/t17-,18+,19+,20+,21+,23+,24+,26+,28+,31+,32+/m1/s1
InChI Key
InChIKey=UEFVDAXLJNYMAZ-ONVRBHABSA-N
IUPAC Name
(2S)-2-[(2S)-4-[(2E,4E,6R)-6-[(1S,2S,5S,6S,7S)-1,6-dimethyl-8,9-dioxaspiro[bicyclo[3.3.1]nonane-2,2'-oxiran]-3-en-7-yl]-4-methylhepta-2,4-dienoyl]-5-hydroxy-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3-oxo-2,3-dihydro-1H-pyrrol-2-yl]-N-methylpropanamide
Traditional IUPAC Name
streptolydigin
SMILES
CNC(=O)[C@@H](C)[C@@H]1N([C@@H]2CC[C@H](O)[C@H](C)O2)C(O)=C(C(=O)\C=C\C(\C)=C\[C@@H](C)[C@@H]2O[C@]3(C)O[C@@H](C=C[C@]33CO3)[C@@H]2C)C1=O
Độ hòa tan
4.61e-02 g/l
logP
3.54
logS
-4.1
pKa (strongest acidic)
4.25
pKa (Strongest Basic)
-0.26
PSA
147.16 Å2
Refractivity
169.64 m3·mol-1
Polarizability
63.69 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
10
H Bond Donor Count
3
Physiological Charge
-2
Number of Rings
5
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Streptolydigin is an antibiotic which works by blocking nucleic acid chain elongation by binding to the polymerase, thus stopping RNA polymerase activity inside a cell. Specifically, it inhibits the assembly of the RNA polymerase II transcription complex and DNA polymerase III transcription. It is active against a number of gram positive bacteria.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04785
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6436180
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505558
ChemSpider
http://www.chemspider.com/Chemical-Structure.191238.html
Wikipedia
http://en.wikipedia.org/wiki/Streptolydigin
... loading
... loading