Tìm theo
Stepronin
Các tên gọi khác (5 ) :
  • Stepronin
  • Stepronine
  • Stepronino
  • Steproninum
  • Tiofacic
antiviral agents, immunosuppressive agents, expectorants
Thuốc Gốc
Small Molecule
CAS: 72324-18-6
ATC: R05CB11
CTHH: C10H11NO4S2
PTK: 273.329
Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as well as the presence of disulfide bonds between these macromolecules and DNA.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H11NO4S2
Phân tử khối
273.329
Monoisotopic mass
273.012949225
InChI
InChI=1S/C10H11NO4S2/c1-6(9(14)11-5-8(12)13)17-10(15)7-3-2-4-16-7/h2-4,6H,5H2,1H3,(H,11,14)(H,12,13)
InChI Key
InChIKey=JNYSEDHQJCOWQU-UHFFFAOYSA-N
IUPAC Name
2-{2-[(thiophen-2-yl)carbonylsulfanyl]propanamido}acetic acid
Traditional IUPAC Name
{2-[(thiophen-2-yl)carbonylsulfanyl]propanamido}acetic acid
SMILES
CC(SC(=O)C1=CC=CS1)C(=O)NCC(O)=O
Độ hòa tan
2.11e-01 g/l
logP
1.27
logS
-3.1
pKa (strongest acidic)
3.56
pKa (Strongest Basic)
-4.6
PSA
83.47 Å2
Refractivity
64.8 m3·mol-1
Polarizability
25.98 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : The drug promotes drainage of mucus from the lungs by thinning the mucus and lubricating the irritated respiratory tract
Cơ Chế Tác Dụng : Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as well as the presence of disulfide bonds between these macromolecules and DNA. An expectorant increases bronchial secretions and mucolytics help loosen thick bronchial secretions. Expectorants reduce the thickness or viscosity of bronchial secretions thus increasing mucus flow that can be removed more easily through coughing, Mucolytics break down the chemical structure of mucus molecules. The mucus becomes thinner and can be removed more easily through coughing.
Chỉ Định : Strepronin is a mucolytic (expectorant) drug.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01423
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=54120
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507364
ChemSpider
http://www.chemspider.com/Chemical-Structure.48889.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748630
Wikipedia
http://en.wikipedia.org/wiki/Stepronin
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