Tìm theo
Stannsoporfin
Các tên gọi khác (3) :
  • SnMP
  • Tin (IV) mesoporphyrin IX dichloride
  • tin-mesoporphyrin
Thuốc Gốc
Small Molecule
CAS: 106344-20-1
Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.
Dược Lực Học : Stannsoporfin is a chemical compound being investigated for use as a medicament in the treatment of infant jaundice. Stannsoporfin is also known to inhibit heme metabolism in mammals, to control the rate of tryptophan metabolism in mammals, and to increase the rate at which heme is excreted by mammals.
Cơ Chế Tác Dụng : Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice. Kernicterus is attributed to high levels of bilirubin, a by-product of heme metabolism. Bilirubin is a bile pigment, which is normally eliminated from the body after conversion into a water-soluble form by the liver. Stannsoporfin's mechanism of action specifically inhibits the enzyme that blocks the conversion of heme into bilirubin.
Dược Động Học :
▧ Absorption :
Not absorbed orally
▧ Half Life :
3.8 hours following i.v. administration of 1 mumole per kg body weight
Chỉ Định : Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Stanate
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04912
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