Tìm theo
Spinosad
Các tên gọi khác (5 ) :
  • 1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-13-[[2R,5S,6R)-5-(dimethylamino) tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimetyl-,(2S,3aSR,5aS,5bS,9S,13S,14R,16aS,16bS)-
  • 1H-as-Indaceno[3,2-d]oxacyclododecin-7,a5-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-13-[[2R,5S,6R)-5-(dimethylamino) tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-metyl-, (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-
  • NAF-144
  • PP-105
  • XDE-105
insecticides, antiscabies agents
Thuốc Gốc
Small Molecule
CAS: 168316-95-8
CTHH: C42H67NO9
PTK: 729.9827
Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species. Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C42H67NO9
Phân tử khối
729.9827
Monoisotopic mass
729.481582747
InChI
InChI=1S/C42H67NO9/c1-10-27-12-11-13-35(52-38-17-16-34(43(5)6)25(4)49-38)24(3)39(45)33-21-31-29(32(33)22-37(44)51-27)15-14-26-19-28(20-30(26)31)50-36-18-23(2)40(46-7)42(48-9)41(36)47-8/h14-15,21,23-32,34-36,38,40-42H,10-13,16-20,22H2,1-9H3/t23-,24-,25-,26-,27+,28-,29-,30-,31-,32+,34+,35+,36-,38+,40+,41+,42-/m1/s1
InChI Key
InChIKey=SRYYCRXKYKWXDQ-PTGKCMAJSA-N
IUPAC Name
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-9-ethyl-14-methyl-2-{[(1R,2S,3R,4S,5R)-2,3,4-trimethoxy-5-methylcyclohexyl]oxy}-1H,2H,3H,3aH,5aH,5bH,6H,7H,9H,10H,11H,12H,13H,14H,15H,16aH,16bH-as-indaceno[3,2-d]oxacyclododecane-7,15-dione
Traditional IUPAC Name
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-9-ethyl-14-methyl-2-{[(1R,2S,3R,4S,5R)-2,3,4-trimethoxy-5-methylcyclohexyl]oxy}-1H,2H,3H,3aH,5aH,5bH,6H,9H,10H,11H,12H,13H,14H,16aH,16bH-as-indaceno[3,2-d]oxacyclododecane-7,15-dione
SMILES
CC[C@H]1CCC[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@@H](C)C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1)O[C@@H]1C[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]1OC
Độ tan chảy
84 - 99.5 °C (Spinosyn A), 161 - 170 °C (Spinosyn D)
Độ sôi
801.515°C
Độ hòa tan
not soluble.
logP
4.0
logS
-5.9
pKa (strongest acidic)
19.45
pKa (Strongest Basic)
8.56
PSA
101.99 Å2
Refractivity
201.03 m3·mol-1
Polarizability
84.92 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
9
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
6
Bioavailability
0
MDDR-Like Rule
true
pKa
8.1
Dược Lực Học : Spinosyn A does not appear to directly interact with any known relevant insecticidal targets, but instead boasts a novel mechanism that resembles a GABA antagonist. Spinosyn A is also slightly more biologically active than spinosyn D.
Cơ Chế Tác Dụng : Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species. Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants. Spinosad is a mixture of spinosyn A and spinosyn D in a 5:1 ratio. This combination causes neuronal hyperexcitation through mostly alteration of nicotinic acetylcholine receptors, which ultimately leads to lice paralysis and death.
Dược Động Học :
▧ Absorption :
Not absorbed if administered topically.
▧ Volume of Distribution :
No distribution if administered topically.
▧ Protein binding :
Not plasma protein bound if administered topically.
Độc Tính : Natroba contains benzyl alcohol, which should be avoided in neonates due to associated severe adverse effects and potential fatality. For use only on the scalp and associated hair. Avoid ingestion and contact with eyes. Spinosad itself is not hazardous by the oral, dermal, ocular, or inhalational routes.
Chỉ Định : Spinosad is indicated for the topical treatment of head lice in children four years old and over and in adults.
Liều Lượng & Cách Dùng : Suspension - Topical - 0.9%
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08823
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D09384
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/52246-929-04
Wikipedia
http://en.wikipedia.org/wiki/Spinosad
RxList
http://fdb.rxlist.com/drugs/drug-155230-spinosad+Top.aspx?drugid=155230&drugname=spinosad+Top&source
PDRhealth
http://www.pdrhealth.com/info/v1us/spinosad
Drugs.com
http://www.drugs.com/mtm/spinosad-topical.html
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