Tìm theo
Spermine
Các tên gọi khác (4 ) :
  • 4,9-Diaza-1,12-dodecanediamine
  • 4,9-Diazadodecane-1,12-diamine
  • N,N'-Bis(3-aminopropyl)-1,4-butanediamine
  • Spermine
dietary supplements, micronutrients, supplements
Thuốc Gốc
Small Molecule
CAS: 71-44-3
CTHH: C10H26N4
PTK: 202.3402
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H26N4
Phân tử khối
202.3402
Monoisotopic mass
202.215746852
InChI
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChI Key
InChIKey=PFNFFQXMRSDOHW-UHFFFAOYSA-N
IUPAC Name
(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
Traditional IUPAC Name
spermine
SMILES
NCCCNCCCCNCCCN
Độ tan chảy
29 °C
Độ sôi
150-150 °C
Độ hòa tan
> 100 mg/mL
logP
-0.7
logS
-2
pKa (Strongest Basic)
11.1
PSA
76.1 Å2
Refractivity
62.56 m3·mol-1
Polarizability
26.69 Å3
Rotatable Bond Count
11
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
4
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism.
Cơ Chế Tác Dụng : A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. [PubChem] Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00127
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1103
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507215
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00750
ChemSpider
http://www.chemspider.com/Chemical-Structure.1072.html
PharmGKB
http://www.pharmgkb.org/drug/PA164781199
Wikipedia
http://en.wikipedia.org/wiki/Spermine
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