Tìm theo
Spectinomycin
Các tên gọi khác (7 ) :
  • Actinospectacina
  • Antibiotic 2233WP
  • Espectinomicina
  • SCM
  • Spectinomicina
  • Spectinomycine
  • Spectinomycinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 1695-77-8
ATC: J01XX04
ĐG : Pfizer Inc. , http://www.pfizer.com
CTHH: C14H24N2O7
PTK: 332.3496
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H24N2O7
Phân tử khối
332.3496
Monoisotopic mass
332.158351132
InChI
InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1
InChI Key
InChIKey=UNFWWIHTNXNPBV-WXKVUWSESA-N
IUPAC Name
(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.0^{3,8}]tetradecan-7-one
Traditional IUPAC Name
spectinomycin
SMILES
[H][C@@]12O[C@H](C)CC(=O)[C@]1(O)O[C@]1([H])[C@@H](NC)[C@@H](O)[C@@H](NC)[C@H](O)[C@@]1([H])O2
Độ hòa tan
Easily soluble in cold water
logP
-2.3
logS
-0.35
pKa (strongest acidic)
8.58
pKa (Strongest Basic)
9.4
PSA
129.51 Å2
Refractivity
75.44 m3·mol-1
Polarizability
33.39 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
9
H Bond Donor Count
5
Physiological Charge
2
Number of Rings
3
Bioavailability
1
Rule of Five
true
pKa
6.95
Dược Lực Học : Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.
Cơ Chế Tác Dụng : An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action.
Dược Động Học :
▧ Absorption :
Rapidly and almost completely absorbed after intramuscular injection.
▧ Protein binding :
Not significant
▧ Half Life :
1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute.
Độc Tính : Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.
Chỉ Định : For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae.
Liều Lượng & Cách Dùng : Powder, for suspension - Intramuscular
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Actinospectacin
  • Công ty :
    Sản phẩm biệt dược : Spectam
  • Công ty :
    Sản phẩm biệt dược : Togamycin
  • Công ty :
    Sản phẩm biệt dược : Trobicin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00919
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=15541
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505032
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C02078
ChemSpider
http://www.chemspider.com/Chemical-Structure.14785.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0009-0566-01
PharmGKB
http://www.pharmgkb.org/drug/PA164781342
Wikipedia
http://en.wikipedia.org/wiki/Spectinomycin
RxList
http://www.rxlist.com/cgi/generic/trobicin.htm
Drugs.com
http://www.drugs.com/mtm/spectinomycin.html
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