Tìm theo
Sparteine
Các tên gọi khác (8 ) :
  • (-)-sparteine
  • d-Sparteine
  • Esparteina
  • Genisteine
  • lupinidine
  • Pachycarpine
  • Sparteinum
  • Sparteinum sulfuricum
oxytocics, anti arrhythmia agents
Thuốc Gốc
Small Molecule
CAS: 90-39-1
ATC: C01BA04
CTHH: C15H26N2
PTK: 234.3803
Sparteine is a class 1a antiarrhythmic agent; a sodium channel blocker. It is an alkaloid and can be extracted from scotch broom. It is the predominant alkaloid in Lupinus mutabilis, and is thought to chelate the bivalents calcium and magnesium. It is not FDA approved for human use as an antiarrhythmic agent, and it is not included in the Vaughn Williams classification of antiarrhythmic drugs.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H26N2
Phân tử khối
234.3803
Monoisotopic mass
234.209598842
InChI
InChI=1S/C15H26N2/c1-3-7-16-11-13-9-12(14(16)5-1)10-17-8-4-2-6-15(13)17/h12-15H,1-11H2/t12-,13-,14-,15-/m0/s1
InChI Key
InChIKey=SLRCCWJSBJZJBV-AJNGGQMLSA-N
IUPAC Name
(1S,2S,9S,10S)-7,15-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadecane
Traditional IUPAC Name
(1S,2S,9S,10S)-7,15-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadecane
SMILES
C1CCN2C[C@@H]3C[C@@H](CN4CCCC[C@@H]34)[C@@H]2C1
Độ tan chảy
30.5 °C
Độ sôi
325 °C
Độ hòa tan
3040 mg/L (at 22 °C)
logP
2.03
logS
-2.4
pKa (Strongest Basic)
9.46
PSA
6.48 Å2
Refractivity
71.82 m3·mol-1
Polarizability
28.4 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
2
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06727
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46937024
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443273
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C10783
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01041
ChemSpider
http://www.chemspider.com/Chemical-Structure.147139.html
PharmGKB
http://www.pharmgkb.org/drug/PA452610
Wikipedia
http://en.wikipedia.org/wiki/Sparteine
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