Tìm theo
Spaglumic Acid
Các tên gọi khác (4 ) :
  • N-(N-Acetyl-l-β-aspartyl)-l-glutamic acid
  • N-Acetyl-l-aspartylglutamate
  • N-Acetylaspartylglutamic acid
  • NAAG
mast cell stabilizers
Thuốc Gốc
Small Molecule
CAS: 4910-46-7
ATC: R01AC05, S01GX03
CTHH: C11H16N2O8
PTK: 304.2533
Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis. Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H16N2O8
Phân tử khối
304.2533
Monoisotopic mass
304.090665498
InChI
InChI=1/C11H16N2O8/c1-5(14)12-7(11(20)21)4-8(15)13-6(10(18)19)2-3-9(16)17/h6-7H,2-4H2,1H3,(H,12,14)(H,13,15)(H,16,17)(H,18,19)(H,20,21)/t6-,7+/s2
InChI Key
InChIKey=GUCKKCMJTSNWCU-JHPDDGAFNA-N
IUPAC Name
(2R)-2-[(3S)-3-carboxy-3-acetamidopropanamido]pentanedioic acid
Traditional IUPAC Name
(2R)-2-[(3S)-3-carboxy-3-acetamidopropanamido]pentanedioic acid
SMILES
CC(=O)N[C@@H](CC(=O)N[C@H](CCC(O)=O)C(O)=O)C(O)=O
Độ hòa tan
3.22e+00 g/l
logP
-2.3
logS
-2
pKa (strongest acidic)
3.01
pKa (Strongest Basic)
-1.5
PSA
170.1 Å2
Refractivity
64.06 m3·mol-1
Polarizability
26.96 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
8
H Bond Donor Count
5
Physiological Charge
-3
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis. Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis. Spaglumic acid is a mast cell stabilizer. Mast cells are involved in producing an allergic response by releasing inflammatory mediators such as histamine. Mast cell stablizers block the release of histamine and other mediators by inhibiting mast cell degranulation, which is the process of releasing these mediators. Inhibition occurs through inhibition of specific calcium channels to stabilize the mast cell and prevent degranulation.
Chỉ Định : Used in patients with allergic conjunctivitis.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Thea
    Sản phẩm biệt dược : Naabak
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08835
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07374
Wikipedia
http://en.wikipedia.org/wiki/N-Acetylaspartylglutamic_acid
Drugs.com
http://www.drugs.com/international/spaglumic-acid.html
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