Tìm theo
Sofosbuvir
Các tên gọi khác (2) :
  • GS-7977
  • PSI-7977
antiviral agents
Thuốc Gốc
Small Molecule
CAS: 1190307-88-0
CTHH: C22H29FN3O9P
PTK: 529.4525
Sofosbuvir is a medication used as part of combination therapy to treat hepatitis C virus (HCV) infection or HCV and HIV co-infection. Sofosbuvir is nucleotide analog inhibitor, which specifically inhibits HCV NS5B polymerase. Sofosbuvir was approved by the FDA in December 2013, and is marketed under the brand name Sovaldi.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H29FN3O9P
Phân tử khối
529.4525
Monoisotopic mass
529.162544258
InChI
InChI=1/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16?,18+,20+,22+,36-/s2
InChI Key
InChIKey=TTZHDVOVKQGIBA-YUFAQMEMNA-N
IUPAC Name
propan-2-yl (2S)-2-{[(S)-{[(3R,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
Traditional IUPAC Name
isopropyl (2S)-2-{[(S)-[(3R,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy(phenoxy)phosphoryl]amino}propanoate
SMILES
CC(C)OC(=O)[C@H](C)N[P@](=O)(OCC1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC1=CC=CC=C1
Độ hòa tan
8.24e-01 g/l
logP
1.28
logS
-2.8
pKa (strongest acidic)
9.38
pKa (Strongest Basic)
-3.9
PSA
152.73 Å2
Refractivity
121.59 m3·mol-1
Polarizability
49.89 Å3
Rotatable Bond Count
11
H Bond Acceptor Count
6
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Sofosbuvir acts against HCV and is categorized as a direct-acting antiviral agent (DAA).
Cơ Chế Tác Dụng : Sofosbuvir is a medication used as part of combination therapy to treat hepatitis C virus (HCV) infection or HCV and HIV co-infection. Sofosbuvir is nucleotide analog inhibitor, which specifically inhibits HCV NS5B polymerase. Sofosbuvir was approved by the FDA in December 2013, and is marketed under the brand name Sovaldi. Sofosbuvir is nucleotide analog inhibitor, which specifically inhibits HCV NS5B polymerase. Sofosbuvir prevents HCV viral replication by binding to the two Mg2+ ions present in HCV NS5B polymerase's GDD active site motif.
Dược Động Học :
▧ Absorption :
When given orally, sofosbuvir reaches its maximum plasma concentration in about 0.5 to 2 hours.
▧ Volume of Distribution :
The volume of distribution for sofosbuvir has yet to be determined.
▧ Protein binding :
Sofosbuvir has a plasma protein binding amount of 61-65%.
▧ Metabolism :
Sofosbuvir is metabolised by the liver to the active metabolite, GS-461203.
▧ Route of Elimination :
Sofosbuvir is eliminated by three routes: urine ( 80%), feces (14%), and respiration (2.5%); however, elimination through the kidneys is the major route.
▧ Half Life :
Sofosbuvir has a terminal half life of 0.4 hours.
▧ Clearance :
The clearance of sofosbuvir has yet to be determined.
Độc Tính : Sofosbuvir, as a single agent, has very mild toxicity. The most common adverse reactions are headache and fatigue.
Chỉ Định : Sofosbuvir is used in combination therapy to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptype 1,2,3, or 4, and to treat HCV and HIV co-infected patients. The combination therapy includes either ribavirin alone or ribavirin and peg-interferon alfa.
Liều Lượng & Cách Dùng : Tablet - Oral - 400 mg
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08934
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D10366
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/61958-1501-1
Wikipedia
http://en.wikipedia.org/wiki/Sofosbuvir
RxList
http://www.rxlist.com/sovaldi-drug.htm
Drugs.com
http://www.drugs.com/sovaldi.html
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