Tìm theo
Sodium Tetradecyl Sulfate
Các tên gọi khác (2) :
  • STS
  • Tetradecyl sodium sulfate
sclerosing solutions, surface active agents
Thuốc Gốc
Small Molecule
CAS: 1191-50-0
ATC: C05BB04
ĐG : Angiodynamics , http://www.angiodynamics.com
CTHH: C14H30O4S
PTK: 294.451
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H30O4S
Phân tử khối
294.451
Monoisotopic mass
294.186480138
InChI
InChI=1S/C14H30O4S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-19(15,16)17/h2-14H2,1H3,(H,15,16,17)
InChI Key
InChIKey=URLJMZWTXZTZRR-UHFFFAOYSA-N
IUPAC Name
(tetradecyloxy)sulfonic acid
Traditional IUPAC Name
tetradecyloxysulfonic acid
SMILES
CCCCCCCCCCCCCCOS(O)(=O)=O
Độ hòa tan
2.62e-03 g/l
logP
5.31
logS
-5
pKa (strongest acidic)
-1.5
PSA
63.6 Å2
Refractivity
78.14 m3·mol-1
Polarizability
35.74 Å3
Rotatable Bond Count
14
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
0
Bioavailability
0
Ghose Filter
true
Dược Lực Học : Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.
Cơ Chế Tác Dụng : An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins. Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.
Độc Tính : LD50=1250 mg/kg (Orally in rat); LD50=3 ml/kg (Skin in rat)
Chỉ Định : For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Tromboject 1 %
    Giá bán buôn : USD >3.46
    Đơn vị tính : ml
  • Biệt dược thương mại : Tromboject 3 %
    Giá bán buôn : USD >3.77
    Đơn vị tính : ml
  • Biệt dược thương mại : Sotradecol 1% vial
    Giá bán buôn : USD >19.68
    Đơn vị tính : ml
  • Biệt dược thương mại : Sotradecol 3% vial
    Giá bán buôn : USD >33.0
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Fibro-Vein
  • Công ty :
    Sản phẩm biệt dược : Sotradecol
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00464
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5248
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505919
ChemSpider
http://www.chemspider.com/Chemical-Structure.5058.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67457-162-02
PharmGKB
http://www.pharmgkb.org/drug/PA164746759
RxList
http://www.rxlist.com/cgi/generic2/sotradecol.htm
Drugs.com
http://www.drugs.com/cdi/sodium-tetradecyl-sulfate.html
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