Tìm theo
Sodium lauryl sulfate
Các tên gọi khác (11 ) :
  • Laurylsiran sodny
  • NaDS
  • Natrium laurylsulfuricum
  • SDS
  • SLS
  • Sodium dodecyl sulfate
  • Sodium dodecyl sulphate
  • Sodium dodecylsulfate
  • Sodium laurilsulfate
  • Sodium lauryl sulfate
  • Sodium lauryl sulphate
surface active agents
Thuốc Gốc
Small Molecule
CAS: 151-21-3
ĐG : Amend
CTHH: C12H25NaO4S
PTK: 288.379
Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H25NaO4S
Phân tử khối
288.379
Monoisotopic mass
288.137124653
InChI
InChI=1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1
InChI Key
InChIKey=DBMJMQXJHONAFJ-UHFFFAOYSA-M
IUPAC Name
sodium dodecyl sulfate
Traditional IUPAC Name
sodium dodecyl sulfate
SMILES
[Na+].CCCCCCCCCCCCOS([O-])(=O)=O
Độ tan chảy
205.5 °C
Độ hòa tan
1E+005 mg/L
logP
1.60
logS
-4.4
pKa (strongest acidic)
-1.5
PSA
66.43 Å2
Refractivity
67.81 m3·mol-1
Polarizability
31.17 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.
Cơ Chế Tác Dụng : Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity. Like other surfactants, SLS is amphiphilic. It thus migrates to the surface of liquids, where its alignment and aggregation with other SLS molecules lowers the surface tension. This allows for easier spreading and mixing of the liquid. SLS has potent protein denaturing activity and inhibits the infectivity of viruses by by solubilizing the viral envelope and/or by denaturing envelope and/or capsid proteins.
Độc Tính : Oral (LD50): Acute: 1288 mg/kg [Rat]
Chỉ Định : SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Anticerumen
  • Công ty :
    Sản phẩm biệt dược : Emal 10
  • Công ty :
    Sản phẩm biệt dược : Empicol
  • Công ty :
    Sản phẩm biệt dược : Genapol LSS
  • Công ty :
    Sản phẩm biệt dược : Irium
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00815
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11166
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01045
PharmGKB
http://www.pharmgkb.org/drug/PA451398
Wikipedia
http://en.wikipedia.org/wiki/Sodium_lauryl_sulfate
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