Tìm theo
Sodium bicarbonate
Các tên gọi khác (12 ) :
  • Baking soda
  • Bicarbonate of soda
  • Carbonic acid monosodium salt
  • e 500
  • e-500
  • e500
  • NaHCO3
  • Natriumhydrogenkarbonat
  • Sodium acid carbonate
  • Sodium bicarbonate
  • Sodium hydrogen carbonate
  • Sodium hydrogencarbonate
Thuốc Gốc
Small Molecule
CAS: 144-55-8
ATC: B05XA02, B05CB04
ĐG : Alaven Pharmaceutical , http://www.alavenpharm.com
CTHH: CHNaO3
PTK: 84.0066
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
CHNaO3
Phân tử khối
84.0066
Monoisotopic mass
83.982338573
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI Key
InChIKey=UIIMBOGNXHQVGW-UHFFFAOYSA-M
IUPAC Name
sodium hydrogen carbonate
Traditional IUPAC Name
sodium bicarbonate
SMILES
[Na+].OC([O-])=O
Độ tan chảy
Decomposes around 50 °C
Độ hòa tan
1E+005 mg/L (at 25 °C)
logP
0.25
logS
0.96
pKa (strongest acidic)
6.05
PSA
60.36 Å2
Refractivity
20.34 m3·mol-1
Polarizability
3.86 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
6.3
Dược Lực Học : Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Cơ Chế Tác Dụng : Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Chỉ Định : Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Tương Tác Thuốc :
  • Atazanavir This gastric pH modifier decreases the levels/effect of atazanavir
  • Benzphetamine Alkalinizing agents such as sodium bicarbonate may decrease the excretion of amphetamines like benzphetamine. Increased clinical effects and/or toxicity may occur. Therapy modification should be considered.
  • Deferiprone Deferiprone may decrease gastrointestinal absorption by chelating to other ions. Interaction is significant so monitor closely.
  • Eltrombopag Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
  • Lithium The urine alkalizer decreases the effect of lithium
  • Memantine Possible increased levels of memantine
  • Methenamine mandelate Urine alkalizer decreases the effect of methenamine
  • Quinidine The antacid increases the effect of quinidine
  • Ticlopidine Sodium bicarbonate may decrease Ticlopidine levels. Administer agents 1 to 2 hours apart.
  • Tipranavir Sodium bicarbonate may decrease the absorption of Tipranavir. Separate administration of the agents and monitor for decreased efficacy of Tipranavir.
  • Trandolapril Sodium bicarbonate may decrease the absorption of Trandolapril. Administration should be spaced.
Liều Lượng & Cách Dùng : Liquid - Oral
Powder - Oral
Solution - Intravenous
Solution / drops - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01390
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=516892
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507049
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C12603
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01203
ChemSpider
http://www.chemspider.com/Chemical-Structure.8609.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/63739-460-21
PharmGKB
http://www.pharmgkb.org/drug/PA451375
Wikipedia
http://en.wikipedia.org/wiki/Sodium_bicarbonate
RxList
http://www.rxlist.com/cgi/generic/sodbic.htm
Drugs.com
http://www.drugs.com/cdi/sodium-bicarbonate.html
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