Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Monoisotopic mass
83.982338573
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI Key
InChIKey=UIIMBOGNXHQVGW-UHFFFAOYSA-M
IUPAC Name
sodium hydrogen carbonate
Traditional IUPAC Name
sodium bicarbonate
Độ tan chảy
Decomposes around 50 °C
Độ hòa tan
1E+005 mg/L (at 25 °C)
pKa (strongest acidic)
6.05
Refractivity
20.34 m3·mol-1
Dược Lực Học :
Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Cơ Chế Tác Dụng :
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Chỉ Định :
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Tương Tác Thuốc :
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Atazanavir
This gastric pH modifier decreases the levels/effect of atazanavir
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Benzphetamine
Alkalinizing agents such as sodium bicarbonate may decrease the excretion of amphetamines like benzphetamine. Increased clinical effects and/or toxicity may occur. Therapy modification should be considered.
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Deferiprone
Deferiprone may decrease gastrointestinal absorption by chelating to other ions. Interaction is significant so monitor closely.
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Eltrombopag
Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
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Lithium
The urine alkalizer decreases the effect of lithium
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Memantine
Possible increased levels of memantine
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Methenamine mandelate
Urine alkalizer decreases the effect of methenamine
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Quinidine
The antacid increases the effect of quinidine
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Ticlopidine
Sodium bicarbonate may decrease Ticlopidine levels. Administer agents 1 to 2 hours apart.
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Tipranavir
Sodium bicarbonate may decrease the absorption of Tipranavir. Separate administration of the agents and monitor for decreased efficacy of Tipranavir.
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Trandolapril
Sodium bicarbonate may decrease the absorption of Trandolapril. Administration should be spaced.
Liều Lượng & Cách Dùng :
Liquid - Oral
Powder - Oral
Solution - Intravenous
Solution / drops - Oral
Tablet - Oral
Tài Liệu Tham Khảo Thêm
National Drug Code Directory