Tìm theo
Silver sulfadiazine
Các tên gọi khác (6 ) :
  • Flamazine
  • Silvadene
  • Silver sulfadiazinate
  • Silver sulfadiazine
  • Silver sulphadiazine
  • Sulfadiazine silver salt
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 22199-08-2
ĐG : Advanced Pharmaceutical Services Inc.
CTHH: C10H9AgN4O2S
PTK: 357.137
Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H9AgN4O2S
Phân tử khối
357.137
Monoisotopic mass
355.949714262
InChI
InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
InChI Key
InChIKey=UEJSSZHHYBHCEL-UHFFFAOYSA-N
IUPAC Name
silver(1+) ion 4-{[(pyrimidin-2-yl)azanidyl]sulfonyl}aniline
Traditional IUPAC Name
silver(1+) 4-(pyrimidin-2-ylazanidylsulfonyl)aniline
SMILES
[Ag+].NC1=CC=C(C=C1)S(=O)(=O)[N-]C1=NC=CC=N1
Độ tan chảy
285 °C
Độ hòa tan
7.87e+00 g/l
logP
0.39
logS
-1.7
pKa (strongest acidic)
6.99
pKa (Strongest Basic)
2.01
PSA
95.17 Å2
Refractivity
63.4 m3·mol-1
Polarizability
24.1 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
6
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.
Cơ Chế Tác Dụng : Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia] Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dược Động Học :
▧ Absorption :
Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Độc Tính : Acute oral toxicity (LD50) in rat is 10001 mg/kg.
Chỉ Định : Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Dermazin
  • Công ty :
    Sản phẩm biệt dược : Flamazine
  • Công ty :
    Sản phẩm biệt dược : Silvadene
  • Công ty :
    Sản phẩm biệt dược : Silverol
  • Công ty :
    Sản phẩm biệt dược : SSD
  • Công ty :
    Sản phẩm biệt dược : Thermazene
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05245
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=441244
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507881
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00433
ChemSpider
http://www.chemspider.com/Chemical-Structure.390017.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/68387-450-01
PharmGKB
http://www.pharmgkb.org/drug/PA164744951
Wikipedia
http://en.wikipedia.org/wiki/Silver_sulfadiazine
RxList
http://www.rxlist.com/cgi/generic/silversulf.htm
Drugs.com
http://www.drugs.com/cdi/silver-sulfadiazine.html
... loading
... loading