Tìm theo
SGS742
Thuốc Gốc
Small Molecule
SGS742 is a selective GABAB receptor antagonist that has shown improvement in attention and memory in prior clinical studies. SGS742 has consistently shown positive benefits on the ability to improve attention, learning and memory.
Cơ Chế Tác Dụng : SGS742 is a selective GABAB receptor antagonist that has shown improvement in attention and memory in prior clinical studies. SGS742 has consistently shown positive benefits on the ability to improve attention, learning and memory. SGS742 blocks the late inhibitory postsynaptic potential and the paired-pulse inhibition of population spikes recorded from CA1 pyramidal neurons of the hippocampus of rats in vitro and in vivo. SGS742 significantly enhances the release of glutamate, aspartate, glycine and somatostatin in vivo. Chronic administration of SGS742 causes an up-regulation of GABA(B) receptors in the frontal cortex of rats. Single doses cause a significant enhancement of the mRNA and protein levels of NGF and BDNF in the cortex and hippocampus of rats.
Dược Động Học :

▧ Half Life :
4 hours
Chỉ Định : Investigated for use/treatment in alzheimer's disease, attention deficit/hyperactivity disorder (ADHD), memory loss, and schizophrenia and schizoaffective disorders.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05010
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