Tìm theo
Sevoflurane
Các tên gọi khác (5 ) :
  • 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
  • Sevofluran
  • Sevoflurane
  • Sevoflurano
  • Sevofluranum
Thuốc Gốc
Small Molecule
CAS: 28523-86-6
ATC: N01AB08
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C4H3F7O
PTK: 200.0548
Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C4H3F7O
Phân tử khối
200.0548
Monoisotopic mass
200.007212153
InChI
InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2
InChI Key
InChIKey=DFEYYRMXOJXZRJ-UHFFFAOYSA-N
IUPAC Name
1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane
Traditional IUPAC Name
sevoflurane
SMILES
FCOC(C(F)(F)F)C(F)(F)F
Độ tan chảy
< 25 °C
Độ sôi
58.5 °C
Độ hòa tan
Very slightly soluble
logP
2.4
logS
-2.1
pKa (strongest acidic)
15.07
pKa (Strongest Basic)
-4.5
PSA
9.23 Å2
Refractivity
23.3 m3·mol-1
Polarizability
9.83 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Cơ Chế Tác Dụng : Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. [Wikipedia] Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor.
Dược Động Học :
▧ Absorption :
Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.
▧ Metabolism :
Relatively little biotransformation, only 5% is metabolized by cytochrome P450 CYP2E1 to hexafluoroisopropanol (HFIP) with release of inorganic fluoride and CO2. No other metabolic pathways have been identified for sevoflurane.
▧ Route of Elimination :
The low solubility of sevoflurane facilitates rapid elimination via the lungs. In vivo metabolism studies suggest that approximately 5% of the sevoflurane dose may be metabolized. Up to 3.5% of the sevoflurane dose appears in the urine as inorganic fluoride.
▧ Half Life :
15-23 hours
Độc Tính : LC50=49881 ppm/hr (rat), LD50=10.8 g/kg (rat)
Chỉ Định : Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Liều Lượng & Cách Dùng : Liquid - Respiratory (inhalation)
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Sevorane
  • Công ty :
    Sản phẩm biệt dược : Sojourn
  • Công ty :
    Sản phẩm biệt dược : Ultane
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01236
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5206
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508591
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07520
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00547
ChemSpider
http://www.chemspider.com/Chemical-Structure.5017.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0074-4456-04
PharmGKB
http://www.pharmgkb.org/drug/PA451341
Wikipedia
http://en.wikipedia.org/wiki/Sevoflurane
RxList
http://www.rxlist.com/cgi/generic/sevoflurane.htm
Drugs.com
http://www.drugs.com/cdi/sevoflurane.html
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