Tìm theo
Seproxetine
Các tên gọi khác (1) :
  • (S)-norfluoxetine
Thuốc Gốc
Small Molecule
CAS: 126924-38-7
CTHH: C16H16F3NO
PTK: 295.2995
Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H16F3NO
Phân tử khối
295.2995
Monoisotopic mass
295.118398754
InChI
InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2
InChI Key
InChIKey=WIQRCHMSJFFONW-UHFFFAOYSA-N
IUPAC Name
1-(3-amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene
Traditional IUPAC Name
1-(3-amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene
SMILES
NCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
Độ hòa tan
9.15e-03 g/l
logP
3.74
logS
-4.5
pKa (Strongest Basic)
9.77
PSA
35.25 Å2
Refractivity
75.59 m3·mol-1
Polarizability
28.13 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed. Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
Dược Động Học :

▧ Half Life :
4-16 days
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06731
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4541
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443277
ChemSpider
http://www.chemspider.com/Chemical-Structure.4382.html
Wikipedia
http://en.wikipedia.org/wiki/Seproxetine
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