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Satumomab Pendetide
Các tên gọi khác (2) :
  • Indium (111In) satumomab pendetide
  • Indium-111 satumomab pendetide
diagnostic agents
Thuốc Gốc
Biotech
CAS: 138955-26-7
ATC: V09IB02
ĐG : EUSA Pharma Inc. , http://www.eusapharma.com
CTHH: C6268H9708N1666O1971S48
PTK: 141478.9000
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6268H9708N1666O1971S48
Phân tử khối
141478.9000
Độ tan chảy
61 °C (FAB fragment), 71 °C (whole mAb)
Độ kỵ nước
-0.427
Điểm đẳng điện tích
7.02
Dược Lực Học : Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors.
Cơ Chế Tác Dụng : Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available. Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Dược Động Học :

▧ Metabolism :
Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production
▧ Half Life :
0.8 hours (mammalian reticulocytes, in vitro)
Chỉ Định : For diagnosis of extrahepatic malignant cancers
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00057
PharmGKB
http://www.pharmgkb.org/drug/PA164745371
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