Tìm theo
Satraplatin
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 129580-63-8
CTHH: C10H22Cl2N2O4Pt
PTK: 500.283
Satraplatin is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. As an investigation drug, it has not yet received U.S. Food and Drug Administration (FDA) approval and is not available in retail pharmacies.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H22Cl2N2O4Pt
Phân tử khối
500.283
Monoisotopic mass
499.060437065
InChI
InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2(3)4;;;;/h6H,1-5,7H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4
InChI Key
InChIKey=CKNPWBAXEKSCRG-UHFFFAOYSA-J
IUPAC Name
platinum(4+) ion cyclohexanamine diacetate amine dichloride
Traditional IUPAC Name
platinum(4+) bis(acetate ion) cyclohexylamine amine dichloride
SMILES
N.[Cl-].[Cl-].[Pt+4].CC([O-])=O.CC([O-])=O.NC1CCCCC1
Độ hòa tan
0.4 mg/ml at pH 1-7.5
logP
1.17
pKa (Strongest Basic)
10.45
PSA
26.02 Å2
Refractivity
30.93 m3·mol-1
Polarizability
12.44 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Cơ Chế Tác Dụng : Satraplatin is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. As an investigation drug, it has not yet received U.S. Food and Drug Administration (FDA) approval and is not available in retail pharmacies. The drug has also been used in the treatment of lung and ovarian cancers. The mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing.
Chỉ Định : Investigated for use/treatment in lung cancer, prostate cancer, and solid tumors.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04996
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=123974
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10240934
ChemSpider
http://www.chemspider.com/Chemical-Structure.110493.html
Wikipedia
http://en.wikipedia.org/wiki/Satraplatin
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