Tìm theo
Sargramostim
Các tên gọi khác (1) :
  • GM-CSF
Thuốc giảm miễn dịch
Thuốc Gốc
Biotech
CAS: 83869-56-1
ATC: L03AA09
ĐG : Bayer Healthcare , http://www.bayerhealthcare.com
CTHH: C639H1006N168O196S8
PTK: 14434.5000
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C639H1006N168O196S8
Phân tử khối
14434.5000
Điểm đẳng điện tích
5.05
Dược Lực Học : Sargramostim is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.
Cơ Chế Tác Dụng : Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein. Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Dược Động Học :

▧ Clearance :
* 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)] * 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)] * 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)] * 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]
Chỉ Định : For the treatment of cancer and bone marrow transplant
Liều Lượng & Cách Dùng : Injection, powder, for solution - Intravenous drip
Injection, powder, for solution - Subcutaneous
Injection, solution - Intravenous drip
Injection, solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Leukine 250 mcg vial
    Giá bán buôn : USD >204.79
    Đơn vị tính : vial
  • Biệt dược thương mại : Bio-immunex capsule
    Giá bán buôn : USD >0.42
    Đơn vị tính : capsule
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00020
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/50419-002-33
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/M13207
PharmGKB
http://www.pharmgkb.org/drug/PA164748631
Wikipedia
http://en.wikipedia.org/wiki/Sargramostim
RxList
http://www.rxlist.com/cgi/generic/sargramostim.htm
Drugs.com
http://www.drugs.com/cdi/sargramostim.html
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