Tìm theo
Salmon Calcitonin
Các tên gọi khác (9 ) :
  • Calcimar
  • Calcitonin 1 precursor
  • Calcitonin-salmon
  • Calcitonin, salmon
  • Cibacalcin
  • Fortical
  • Miacalcin
  • Salmon calcitonin
  • Salmotonin
bone density conservation agents, antihypercalcemic agents, anti osteporotic agents
Thuốc Gốc
Biotech
CAS: 47931-85-1
ATC: H05BA01
ĐG : Apotex Inc. , http://www.apotex.com
CTHH: C145H240N44O48S2
PTK: 3431.8530
Synthetic peptide, 32 residues long formulated as a nasal spray.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C145H240N44O48S2
Phân tử khối
3431.8530
Độ kỵ nước
-0.537
Điểm đẳng điện tích
8.86
Dược Lực Học : Calcitonin inhibits bone resorption by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass and a reduction in plasma calcium levels. It also promotes the renal excretion of ions such as calcium, phosphate, sodium, magnesium, and potassium by decreasing tubular reabsorption. In consequence, there is an increase in the jejunal secretion of water, sodium, potassium, and chloride.
Cơ Chế Tác Dụng : Synthetic peptide, 32 residues long formulated as a nasal spray. Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.
Dược Động Học :
▧ Absorption :
Salmon calcitonin is rapidly absorbed and eliminated. Bioavailability following subcutaneous and intramuscular injection in humans is high and similar for the two routes of administration (71% and 66%, respectively). Via the nasal route, the bioavailability varies between 3 to 5% relative to IM.
▧ Volume of Distribution :
0.15 to 0.3 L/kg
▧ Protein binding :
30 to 40%
▧ Metabolism :
Salmon calcitonin is primarily and almost exclusively degraded in the kidneys, forming pharmacologically inactive fragments of the molecule. It is also metabolized in the blood and the peripheral tissue.
▧ Route of Elimination :
Urine. Studies with injectable calcitonin show increases in the excretion of filtered phosphate, calcium, and sodium by decreasing their tubular reabsorption in the kidney.
▧ Half Life :
Half-life elimination (terminal): I.M. 58 minutes; SubQ 59 to 64 minutes; Nasal: ~18 to 23 minutes
Độc Tính : Salmon calcitonin was shown to inhibit lactation in animals and is not recommend in nursing mothers. While research in animals have shown a decrease in fetal weight, no studies have yet shown similar results in humans. It is recommended however to proceed carefully when administering salmon calcitonin to pregnant women and consider if the benefits outweigh the risks. Because of its protein nature, salmon calcitonin may provoke an allergy reaction (bronchospams and swelling of the tongue/throat) that can turn into a full-blown anaphylactic response. The manufacturer also reports an increase in the risk of malignancies from oral route (0.7%) to intranasal route (2.4%) compared to placebo. The same may apply to IV, IM and SC routes since the systemic exposure is higher in those cases. Nausea is noticeable in some patients but tends to decrease with continued administration. Rhinitis, headaches and back pain have also been reported among others.
Chỉ Định : Used in the treatment of symptomatic Paget's disease for patients unresponsive to alternate treatments or intolerant to such treatments. In addition, it is used in emergency situations when serum calcium levels must be decreased quickly until the underlying condition is identified. It can also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide, oral phosphate or corticosteroids, or other agents. Calcitonin can be used in patients with azotemia and cases where intravenous fluids would be contraindicated due to limited cardiac reserves. Also for the treatment of post-menopausal osteoporosis in women more than 5 years post-menopause.
Tương Tác Thuốc :
  • Lithium Monitor therapy because calcitonin may reduce the serum concentration of lithium.
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Liquid - Nasal
Solution - Intramuscular
Solution - Nasal
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Calcimar
  • Công ty :
    Sản phẩm biệt dược : Fortical
  • Công ty : Novartis
    Sản phẩm biệt dược : Miacalcin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00017
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06865
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00249
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/60505-0823-6
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/Y00765
PharmGKB
http://www.pharmgkb.org/drug/PA448715
Wikipedia
http://en.wikipedia.org/wiki/Calcitonin
RxList
http://www.rxlist.com/cgi/generic2/calcit.htm
... loading
... loading