Tìm theo
Salicylic acid
Các tên gọi khác (5 ) :
  • 2-Carboxyphenol
  • 2-Hydroxybenzoic acid
  • O-carboxyphenol
  • O-hydroxybenzoic acid
  • Salicylic acid
Thuốc dùng điều trị mắt, tai mũi họng
Thuốc Gốc
Small Molecule
CAS: 69-72-7
ATC: D11AC30, N02BA04
ĐG : 7 Oaks Pharmaceutical Corp.
CTHH: C7H6O3
PTK: 138.1207
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C7H6O3
Phân tử khối
138.1207
Monoisotopic mass
138.031694058
InChI
InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
InChI Key
InChIKey=YGSDEFSMJLZEOE-UHFFFAOYSA-N
IUPAC Name
2-hydroxybenzoic acid
Traditional IUPAC Name
salicyclic acid
SMILES
OC(=O)C1=CC=CC=C1O
Độ tan chảy
158 °C
Độ sôi
211 °C at 2.00E+01 mm Hg
Độ hòa tan
2240 mg/L (at 25 °C)
logP
2.26
logS
-1.82
pKa (strongest acidic)
2.79
pKa (Strongest Basic)
-6.3
PSA
57.53 Å2
Refractivity
35.3 m3·mol-1
Polarizability
12.81 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
caco2 Permeability
-4.79
pKa
2.97
Dược Lực Học : Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.
Cơ Chế Tác Dụng : A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis.
Độc Tính : Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Chỉ Định : Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
Liều Lượng & Cách Dùng : Cream - Topical
Disc - Topical
Gel - Topical
Gel - Topical
Liquid - Intravenous
Liquid - Oral
Liquid - Topical
Lotion - Topical
Ointment - Topical
Patch - Topical
Plaster - Topical
Powder - Topical
Powder - Topical
Shampoo - Topical
Solution - Topical
Solution / drops - Oral
Spray - Topical
Stick - Topical
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Compound W
  • Công ty :
    Sản phẩm biệt dược : Dr. Scholl's Callus Removers
  • Công ty :
    Sản phẩm biệt dược : Dr. Scholl's Corn Removers
  • Công ty :
    Sản phẩm biệt dược : Dr. Scholl's Wart Remover Kit
  • Công ty :
    Sản phẩm biệt dược : Duofil Wart Remover
  • Công ty :
    Sản phẩm biệt dược : Duoplant
  • Công ty :
    Sản phẩm biệt dược : Ionil Plus shampoo
  • Công ty :
    Sản phẩm biệt dược : Keralyt
  • Công ty :
    Sản phẩm biệt dược : Salonil
  • Công ty :
    Sản phẩm biệt dược : Stridex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00936
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=338
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504942
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00805
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00097
ChemSpider
http://www.chemspider.com/Chemical-Structure.331.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26193
PharmGKB
http://www.pharmgkb.org/drug/PA451299
Wikipedia
http://en.wikipedia.org/wiki/Salicyclic_acid
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