Tìm theo
S-8184
Thuốc Gốc
Small Molecule
S8184 is a cremophor free, vitamin E based paclitaxel emulsion incorporating a p glycoprotein inhibitor and particle size based tumor targeting designed to reduce toxicity, allow bolus dosing in 15 minutes, and potentially increase efficacy.
Cơ Chế Tác Dụng : S8184 is a cremophor free, vitamin E based paclitaxel emulsion incorporating a p glycoprotein inhibitor and particle size based tumor targeting designed to reduce toxicity, allow bolus dosing in 15 minutes, and potentially increase efficacy. S-8184 binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions; tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump.
Chỉ Định : Ovarian cancer or primary peritoneal carcinoma
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : TOCOSOL paclitaxel
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05281
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