Tìm theo
Rosoxacin
Các tên gọi khác (7 ) :
  • Acrosoxacin
  • ROS
  • Rosoxacin
  • Rosoxacine
  • Rosoxacino
  • Rosoxacinum
  • Roxadyl
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 40034-42-2
ATC: J01MB01
CTHH: C17H14N2O3
PTK: 294.3047
Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H14N2O3
Phân tử khối
294.3047
Monoisotopic mass
294.100442324
InChI
InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
InChI Key
InChIKey=XBPZXDSZHPDXQU-UHFFFAOYSA-N
IUPAC Name
1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
Traditional IUPAC Name
rosoxacin
SMILES
CCN1C=C(C(O)=O)C(=O)C2=C1C=C(C=C2)C1=CC=NC=C1
Độ tan chảy
290 °C
Độ hòa tan
0.0209 mg/mL at 25 °C
logP
3
logS
-3.5
pKa (strongest acidic)
6.18
pKa (Strongest Basic)
4.9
PSA
70.5 Å2
Refractivity
83.06 m3·mol-1
Polarizability
30.8 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
5
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Cơ Chế Tác Dụng : Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock. Rosoxacin binds to and inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Chỉ Định : For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00817
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=287180
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508469
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02305
ChemSpider
http://www.chemspider.com/Chemical-Structure.253208.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776843
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