Tìm theo
Rolitetracycline
Các tên gọi khác (7 ) :
  • N-(1-Pyrrolidinylmethyl)-tetracycline
  • N-(Pyrrolidinomethyl)tetracycline
  • Pyrrolidino-methyl-tetracycline
  • Reverin
  • Rolitetraciclina
  • Rolitetracyclinum
  • Synterin
tetracyclines
Thuốc Gốc
Small Molecule
CAS: 751-97-3
CTHH: C27H33N3O8
PTK: 527.5662
A pyrrolidinylmethyl tetracycline. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C27H33N3O8
Phân tử khối
527.5662
Monoisotopic mass
527.226765047
InChI
InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
InChI Key
InChIKey=HMEYVGGHISAPJR-IAHYZSEUSA-N
IUPAC Name
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Traditional IUPAC Name
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
SMILES
[H][C@@]12C[C@@]3([H])C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCN1CCCC1)=C(O)[C@H]2N(C)C
Độ hòa tan
5.55E+005 mg/L
logP
-3.8
logS
-2.5
pKa (strongest acidic)
0.31
pKa (Strongest Basic)
8.24
PSA
170.87 Å2
Refractivity
139.45 m3·mol-1
Polarizability
54.05 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
10
H Bond Donor Count
6
Physiological Charge
-1
Number of Rings
5
Bioavailability
0
Cơ Chế Tác Dụng : A pyrrolidinylmethyl tetracycline. [PubChem] Rolitetracycline is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
Độc Tính : Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).
Chỉ Định : Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.
Tương Tác Thuốc :
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01301
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5282179
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507805
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02282
ChemSpider
http://www.chemspider.com/Chemical-Structure.4445374.html
PharmGKB
http://www.pharmgkb.org/drug/PA164779049
Wikipedia
http://en.wikipedia.org/wiki/Rolitetracycline
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