Tìm theo
RK-0202
Thuốc Gốc
Small Molecule
CTHH: C5H9NO3S
PTK: 163.195
A substance that is being studied in the prevention of oral mucositis in patients receiving radiation therapy or chemotherapy for head and neck cancer. It is an oral polymer matrix-based rinse formulation that contains N-acetylcysteine, an antioxidant amino acid derivative with antiinflammatory properties.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H9NO3S
Phân tử khối
163.195
Monoisotopic mass
163.030313849
InChI
InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChI Key
InChIKey=PWKSKIMOESPYIA-BYPYZUCNSA-N
IUPAC Name
(2R)-2-acetamido-3-sulfanylpropanoic acid
Traditional IUPAC Name
acetylcysteine
SMILES
CC(=O)N[C@@H](CS)C(O)=O
Độ hòa tan
5.09e+00 g/l
logP
-0.71
logS
-1.5
pKa (strongest acidic)
3.82
pKa (Strongest Basic)
-1.5
PSA
66.4 Å2
Refractivity
37.67 m3·mol-1
Polarizability
15.34 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : A substance that is being studied in the prevention of oral mucositis in patients receiving radiation therapy or chemotherapy for head and neck cancer. It is an oral polymer matrix-based rinse formulation that contains N-acetylcysteine, an antioxidant amino acid derivative with antiinflammatory properties. RK-0202, an oral rinse for the prevention and treatment of mucositis, is based on the company's ProGelz technology and is comprised of the potent antioxidant N-acetylcysteine in a polymer matrix.
Chỉ Định : Investigated for use/treatment in adverse effects (chemotherapy).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05436
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