Tìm theo
Ritodrine
Các tên gọi khác (5 ) :
  • DU-21220
  • Ritodrina
  • Ritodrine
  • Ritodrinium
  • Yutopar
sympathomimetics, adrenergic beta 2 receptor agonists, tocolytic agents
Thuốc Gốc
Small Molecule
CAS: 26652-09-5
ATC: G02CA01
ĐG : Solvay Pharmaceuticals , http://global.abbottgrowth.com
CTHH: C17H21NO3
PTK: 287.3535
Adrenergic beta-agonist used to control premature labor. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H21NO3
Phân tử khối
287.3535
Monoisotopic mass
287.152143543
InChI
InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1
InChI Key
InChIKey=IOVGROKTTNBUGK-SJCJKPOMSA-N
IUPAC Name
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
Traditional IUPAC Name
ritodrine
SMILES
C[C@H](NCCC1=CC=C(O)C=C1)[C@H](O)C1=CC=C(O)C=C1
Độ tan chảy
88-90 °C
Độ hòa tan
Complete
logP
2.4
logS
-3.2
pKa (strongest acidic)
9.15
pKa (Strongest Basic)
9.81
PSA
72.72 Å2
Refractivity
83.02 m3·mol-1
Polarizability
31.56 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
Cơ Chế Tác Dụng : Adrenergic beta-agonist used to control premature labor. [PubChem] Ritodrine is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.
Dược Động Học :

▧ Protein binding :
~56%
▧ Metabolism :
Hepatic, by both the mother and fetus
▧ Half Life :
1.7-2.6 hours
Độc Tính : LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV)
Chỉ Định : For the treatment and prophylaxis of premature labour
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Yutopar
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00867
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=33572
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505273
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07239
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02359
ChemSpider
http://www.chemspider.com/Chemical-Structure.30971.html
PharmGKB
http://www.pharmgkb.org/drug/PA451258
Wikipedia
http://en.wikipedia.org/wiki/Ritodrine
Drugs.com
http://www.drugs.com/cons/ritodrine-oral-intravenous.html
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