Tìm theo
Ribostamycin
Các tên gọi khác (7 ) :
  • 5-Amino-2-Aminomethyl-6-[4,6-Diamino-2-(3,4-Dihydroxy-5-Hydroxymethyl-Tetrahydro-Furan-2-Yloxy)-3-Hydroxy-Cyclohexyloxy]-Tetrahydro-Pyran-3,4-Diol
  • Ribastamin
  • RIO
  • SF-733
  • Vistamycin
  • Xylostacin
  • Xylostasin
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 25546-65-0
ATC: J01GB10
CTHH: C17H34N4O10
PTK: 454.4727
A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H34N4O10
Phân tử khối
454.4727
Monoisotopic mass
454.227493328
InChI
InChI=1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13+,14-,15-,16+,17-/m0/s1
InChI Key
InChIKey=NSKGQURZWSPSBC-NLZFXWNVSA-N
IUPAC Name
(2S,3R,4S,5S,6R)-5-amino-2-(aminomethyl)-6-{[(1S,2S,3R,4S,6R)-4,6-diamino-2-{[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol
Traditional IUPAC Name
ribostamycin
SMILES
NC[C@@H]1O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O)[C@@H]2O[C@@H]2O[C@@H](CO)[C@H](O)[C@H]2O)[C@@H](N)[C@H](O)[C@H]1O
Độ tan chảy
193.5 °C
Độ hòa tan
8.87e+01 g/l
logP
-6.4
logS
-0.71
pKa (strongest acidic)
12.19
pKa (Strongest Basic)
9.93
PSA
262.38 Å2
Refractivity
100.17 m3·mol-1
Polarizability
44.43 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
14
H Bond Donor Count
10
Physiological Charge
4
Number of Rings
3
Bioavailability
0
MDDR-Like Rule
true
pKa
7.7
Cơ Chế Tác Dụng : A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. [PubChem] Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. However, their exact mechanism of action is not fully known.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB03615
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46936732
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505351
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01759
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