Tìm theo
Riboflavin
Các tên gọi khác (14 ) :
  • 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
  • 6,7-Dimethyl-9-D-ribitylisoalloxazine
  • 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
  • 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
  • 7,8-Dimethyl-10-ribitylisoalloxazine
  • e101
  • Lactoflavin
  • Lactoflavine
  • Riboflavin
  • Riboflavina
  • Riboflavine
  • Riboflavinum
  • Vitamin B2
  • Vitamin G
Vitamin
Thuốc Gốc
Small Molecule
CAS: 83-88-5
ATC: A11HA04
ĐG : Amend
CTHH: C17H20N4O6
PTK: 376.3639
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H20N4O6
Phân tử khối
376.3639
Monoisotopic mass
376.138284392
InChI
InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
InChI Key
InChIKey=AUNGANRZJHBGPY-SCRDCRAPSA-N
IUPAC Name
7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
Traditional IUPAC Name
riboflavin
SMILES
CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
Độ tan chảy
280 dec °C
Độ hòa tan
84.7 mg/L (at 25 °C)
logP
-1.46
logS
-3.68
pKa (strongest acidic)
6.97
pKa (Strongest Basic)
0.76
PSA
155.05 Å2
Refractivity
96.27 m3·mol-1
Polarizability
37.5 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
9
H Bond Donor Count
5
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
pKa
10.2
Dược Lực Học : Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.
Cơ Chế Tác Dụng : Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem] Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
Dược Động Học :
▧ Absorption :
Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
▧ Protein binding :
60%
▧ Metabolism :
Hepatic.
▧ Half Life :
66-84 minutes
Chỉ Định : For the treatment of ariboflavinosis (vitamin B2 deficiency).
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Bisulase
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00140
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=493570
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507342
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00255
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00050
ChemSpider
http://www.chemspider.com/Chemical-Structure.6501.html
PharmGKB
http://www.pharmgkb.org/drug/PA451242
Wikipedia
http://en.wikipedia.org/wiki/Riboflavin
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/rib_0263.shtml
Drugs.com
http://www.drugs.com/mtm/riboflavin.html
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