Tìm theo
Ribavirin Monophosphate
Thuốc Gốc
Small Molecule
CAS: 40925-28-8
CTHH: C8H13N4O8P
PTK: 324.1846
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H13N4O8P
Phân tử khối
324.1846
Monoisotopic mass
324.047099924
InChI
InChI=1S/C8H13N4O8P/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(20-8)1-19-21(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H2,16,17,18)/t3-,4-,5+,8+/m0/s1
InChI Key
InChIKey=SDWIOXKHTFOULX-PDNLFSCWSA-N
IUPAC Name
{[(2S,3R,4R,5R)-5-(3-carbamoyl-1H-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional IUPAC Name
[(2S,3R,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic acid
SMILES
NC(=O)C1=NN(C=N1)[C@@H]1O[C@@H](COP(O)(O)=O)[C@H](O)[C@H]1O
Độ hòa tan
3.34e+00 g/l
logP
-2.9
logS
-2
pKa (strongest acidic)
1.23
pKa (Strongest Basic)
-1.2
PSA
190.25 Å2
Refractivity
75.45 m3·mol-1
Polarizability
26.6 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
9
H Bond Donor Count
5
Physiological Charge
-2
Number of Rings
2
Bioavailability
1
Rule of Five
true
Tương Tác Thuốc :
  • Abacavir Ribavirin Monophosphate may increase the hepatotoxicity of reverse transcriptase inhibitors (nucleoside) such as Abacavir. Lactic acidosis may occur. Consider modifying therapy.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01693
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5748447
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504726
ChemSpider
http://www.chemspider.com/Chemical-Structure.284811.html
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