Tìm theo
RHIIP
Các tên gọi khác (1) :
  • Recombinant human insulin inhalation powder
Thuốc Gốc
Biotech
RHIIP is a powder form of recombinant insulin for inhalation administration. It is being developed by Baxter Healthcare Corporation.
Dược Lực Học : RHIIP is made using Baxter’s proprietary PROMAXX formulation technology. Unlike other dry powder formulations of insulin, RHIIP is 95 percent insulin and does not rely on the use of inactive ingredients to facilitate delivery to the deep lung. Study data show that RHIIP had a faster onset of action than SC (time to reach 10 percent of total area under the glucose infusion rate (GIR) curve 73 vs 95 min.; GIR-tmax 173 versus 218 min., p<0.0001). Duration of action (371 vs 366 min.) and total metabolic effect (GIR-AUC0-10h of 2,734 vs 2,482 mg/kg) were comparable. Pharmacokinetic results were in accordance with these findings: RHIIP was absorbed faster (time to reach 10 percent of total area under the insulin curves 44 vs 66 min., p<0.0001), and maximum insulin levels were reached earlier (86 vs 141 min., p=0.002).
Cơ Chế Tác Dụng : RHIIP is a powder form of recombinant insulin for inhalation administration. It is being developed by Baxter Healthcare Corporation. Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism.
Dược Động Học :
▧ Absorption :
The bioavailability of RHIIP relative to SC was more than 12 percent.
▧ Metabolism :
Insulin is predominantly cleared by metabolic degradation via a receptor-mediated process.
Chỉ Định : Intended for the treatment of Diabetes Mellitus Type 1 and 2.
Liều Lượng & Cách Dùng : Powder, metered - Respiratory (inhalation)
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05215
... loading
... loading