Tìm theo
Reteplase
Các tên gọi khác (4 ) :
  • t- PA
  • t-plasminogen activator
  • Tissue-type plasminogen activator precursor
  • tPA
fibrinolytic agents, thrombolytic agents
Thuốc Gốc
Biotech
CAS: 133652-38-7
ATC: B01AD07
ĐG : EKR Therapeutics Inc. , http://www.ekrtx.com
CTHH: C1736H2671N499O522S22
PTK: 39589.6000
Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase - kringle-1, finger, and epidermal growth factor (EGF).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C1736H2671N499O522S22
Phân tử khối
39589.6000
Độ tan chảy
60 °C
Độ kỵ nước
-0.435
Điểm đẳng điện tích
6.86
Dược Lực Học : Reteplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
Cơ Chế Tác Dụng : Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase - kringle-1, finger, and epidermal growth factor (EGF). Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
Chỉ Định : For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
Tương Tác Thuốc :
  • Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
  • Ticlopidine Increased bleeding risk. Monitor for signs of bleeding.
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Intravenous bolus
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Retavase vial half-kit
    Giá bán buôn : USD >2605.93
    Đơn vị tính : vial
Nhà Sản Xuất
  • Công ty : Centocor
    Sản phẩm biệt dược : Retavase
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00015
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/24477-041-02
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/L00153
PharmGKB
http://www.pharmgkb.org/drug/PA164743728
Wikipedia
http://en.wikipedia.org/wiki/Reteplase
RxList
http://www.rxlist.com/cgi/generic2/reteplase.htm
Drugs.com
http://www.drugs.com/cdi/reteplase.html
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